1. MAPK/ERK Pathway
  2. Raf
  3. HG6-64-1

HG6-64-1 (Synonyms: HMSL 10017-101-1)

Cat. No.: HY-12291 Purity: >98.0%
Handling Instructions

HG6-64-1 is a potent and selective B-Raf inhibitor extracted from patent WO 2011090738 A2, example 9 (XI-1); has a IC50 of 0.09 μM on B-raf V600E transformed Ba/F3 cells.

For research use only. We do not sell to patients.

HG6-64-1 Chemical Structure

HG6-64-1 Chemical Structure

CAS No. : 1315329-43-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 534 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

HG6-64-1 is a potent and selective B-Raf inhibitor extracted from patent WO 2011090738 A2, example 9 (XI-1); has a IC50 of 0.09 μM on B-raf V600E transformed Ba/F3 cells.

IC50 & Target[1]

B-RafV600E

0.09 μM (IC50, in Ba/F3 cells)

Molecular Weight

577.64

Formula

C₃₂H₃₄F₃N₅O₂

CAS No.

1315329-43-1

SMILES

O=C(NC1=CC=C(CN2CCN(CC)CC2)C(C(F)(F)F)=C1)C3=CC=C(C)C(/C=C/C4=CN=C(NC=C5)C5=C4OC)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (173.12 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7312 mL 8.6559 mL 17.3118 mL
5 mM 0.3462 mL 1.7312 mL 3.4624 mL
10 mM 0.1731 mL 0.8656 mL 1.7312 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3 mg/mL (5.19 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 3 mg/mL (5.19 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References

Purity: >98.0%

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Keywords:

HG6-64-1HMSL 10017-101-1RafRaf kinasesInhibitorinhibitorinhibit

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Product Name:
HG6-64-1
Cat. No.:
HY-12291
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