PROTAC SMARCA2/4 degrader-41
PROTAC SMARCA2/4 degrader-41 is a SMARCA2/4 PROTAC degrader with a DC50 and IC50 both < 0.1 μM. PROTAC SMARCA2/4 degrader-41 is applicable to research on SMARCA2/4-related or SMARCA2/4-deficient cancers.
(Pink: SMARCA2 and SMARCA4 ligand (HY-183063); Blue: VHL ligand (HY-159465); Black: linker).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 2892523-74-7
- Formule: C49H62N10O6S
- Masse moléculaire:919.14
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
[1]|
SMARCA2 |
SMARCA4 |
VHL |
In Vitro
SMARCA2 shares high homology (up to 75%) with SMARCA4. SMARCA4 frequently undergoes mutations (i.e., deletion or inactivation) in primary tumors, particularly in lung cancer (12%), melanoma, liver cancer and pancreatic cancer. In SMARCA4-mutated (deleted) cancer cell lines, SMARCA2 is one of the most critical essential genes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2892523-74-7
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Masse moléculaire 919.14
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Formule C49H62N10O6S
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SMILES
OC(C=CC=C1)=C1C2=NN=C(NC3)C(NC3(CC4)CCN4CC5CCN(CC5)CCOC6=NOC([C@@H](C(C)C)C(N7[C@@H](C[C@H](C7)O)C(N[C@H](C8=CC=C(C9=C(N=CS9)C)C=C8)C)=O)=O)=C6)=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC SMARCA2/4 degrader-41 Related Classifications
HY-153425 Related Classifications
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