1. Stem Cell/Wnt
  2. YAP
  3. YAP/TAZ inhibitor-1

YAP/TAZ inhibitor-1 

Cat. No.: HY-111429 Purity: 98.04%
Handling Instructions

YAP/TAZ inhibitor-1 is a YAP/TAZ inhibitor extracted from patent WO2017058716A1, Compound 1, has an IC50 of <0.100 μΜ in firefly luciferase assay.

For research use only. We do not sell to patients.

YAP/TAZ inhibitor-1 Chemical Structure

YAP/TAZ inhibitor-1 Chemical Structure

CAS No. : 2093565-23-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 479 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

YAP/TAZ inhibitor-1 is a YAP/TAZ inhibitor extracted from patent WO2017058716A1, Compound 1, has an IC50 of <0.100 μΜ in firefly luciferase assay[1].

Molecular Weight

621.81

Formula

C₃₃H₃₉N₃O₅S₂

CAS No.

2093565-23-0

SMILES

O=S(C1=CC2=C(C=C1)C3=C(C=C(S(=O)(C4CCC(C)(C)CC4)=O)C=C3)/C2=N\O)(N5CCN(C(C6=CC=CC=C6)C)CC5)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (160.82 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6082 mL 8.0410 mL 16.0821 mL
5 mM 0.3216 mL 1.6082 mL 3.2164 mL
10 mM 0.1608 mL 0.8041 mL 1.6082 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.02 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (4.02 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 2.5 mg/mL (4.02 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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YAP/TAZ inhibitor-1
Cat. No.:
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