1. Protein Tyrosine Kinase/RTK
  2. RET
  3. RET-IN-1

RET-IN-1 

Cat. No.: HY-112950
Handling Instructions

RET-IN-1 is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 552, has IC50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively .

For research use only. We do not sell to patients.

RET-IN-1 Chemical Structure

RET-IN-1 Chemical Structure

CAS No. : 2222755-14-6

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Description

RET-IN-1 is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 552, has IC50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively [1].

IC50 & Target

IC50: 1 nM (RETWT), 7 nM (RETV804M), 101 nM (RETG810R)

Molecular Weight

553.61

Formula

C₂₉H₃₁N₉O₃

CAS No.

2222755-14-6

SMILES

N#CC1=C2C(C3=NC=C(N4CC(C5)N(CC6=CC=C(OC)N=C6)C5C4)N=C3)=CC(OC[[email protected]]7CNCCO7)=CN2N=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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RET-IN-1
Cat. No.:
HY-112950
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