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Cat. No.: HY-N8551

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(5E)-7-Oxozeaenol

(5E)-7-Oxozeaenol is an active fungal extract that is cytotoxic. (5E)-7-Oxozeaenol exhibits antibacterial, mitochondrial transmembrane potential, and NF-κB effects.

For research use only. We do not sell to patients.

CAS No.: 1198574-97-8
Formula: C₁₉H₂₂O₇
Molecular Weight:362.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

(5E)-7-Oxozeaenol Chemical Structure

CAS No.: 1198574-97-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

(5E)-7-Oxozeaenol is an active fungal extract that is cytotoxic. (5E)-7-Oxozeaenol exhibits antibacterial, mitochondrial transmembrane potential, and NF-κB effects^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	11.5 μM Compound: 4	Inhibition of NFkappa p65 isolated from nuclear extract of human HeLa cells by ELISA Inhibition of NFkappa p65 isolated from nuclear extract of human HeLa cells by ELISA	[PMID: 21513293]
HT-29	IC₅₀	4.4 μM Compound: 4	Cytotoxicity against human HT-29 cells after 72 hrs by MTS assay Cytotoxicity against human HT-29 cells after 72 hrs by MTS assay	[PMID: 21513293]
MCF7	IC₅₀	4.9 μM Compound: 4	Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay	[PMID: 21513293]
MDA-MB-435	IC₅₀	5.5 μM Compound: 4	Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTS assay Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTS assay	[PMID: 21513293]
NCI-H460	IC₅₀	1.2 μM Compound: 4	Cytotoxicity against human H460 cells after 72 hrs by MTS assay Cytotoxicity against human H460 cells after 72 hrs by MTS assay	[PMID: 21513293]
SF-268	IC₅₀	5.6 μM Compound: 4	Cytotoxicity against human SF268 cells after 72 hrs by MTS assay Cytotoxicity against human SF268 cells after 72 hrs by MTS assay	[PMID: 21513293]
Splenocyte	IC₅₀	6 μM Compound: 14	Immunosuppressive activity in BALB/c mouse splenocytes assessed as inhibition of concanavalin A-stimulated T-cell proliferation incubated for 48 hrs by MTT assay Immunosuppressive activity in BALB/c mouse splenocytes assessed as inhibition of concanavalin A-stimulated T-cell proliferation incubated for 48 hrs by MTT assay	[PMID: 33544615]
Splenocyte	IC₅₀	6.2 μM Compound: 14	Immunosuppressive activity in BALB/c mouse splenocytes assessed as inhibition of LPS-stimulated B-cell proliferation incubated for 48 hrs by MTT assay Immunosuppressive activity in BALB/c mouse splenocytes assessed as inhibition of LPS-stimulated B-cell proliferation incubated for 48 hrs by MTT assay	[PMID: 33544615]

In Vitro

(5E)-7-Oxozeaenol inhibits different cancer cell lines with IC₅₀s of 4.9 μM (MCF-7), 1.2 μM (H460), 5.6 μM (SF268), 4.4 μM (HT-29), 5.5 μM (MDA-MB-435), respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1198574-97-8
Molecular Weight 362.37
Formula C₁₉H₂₂O₇
SMILES

OC1=C2C(/C=C/C[C@@H]([C@@H](C(/C=C/C[C@@H](OC2=O)C)=O)O)O)=CC(OC)=C1
Structure Classification
- Phenols
- Monophenols
Initial Source
- Microorganisms
MSX 63935
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ayers S, et al. Resorcylic acid lactones with cytotoxic and NF-κB inhibitory activities and their structure-activity relationships. J Nat Prod. 2011 May 27;74(5):1126-31. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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