SENP1-IN-3
Based on 1 Customer Validation
SENP1-IN-3 is a specific deSUMOylation protease 1 (SENP1) inhibitor extracted from patent CN110627860, Compound 17. SENP1-IN-3 is developed for tumor radiosensitivity enhancement.
For research use only. We do not sell to patients.
- Purity: 99.84%
- CAS No.: 2416910-59-1
- Formula: C36H58N2O4
- Molecular Weight:582.86
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Metabolism/Protease Compound Library
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Anti-Cancer Compound Library
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Oxygen Sensing Compound Library
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Ubiquitination Compound Library
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Anti-Liver Cancer Compound Library
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Metabolic Enzyme Compound Library
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Highly Selective Inhibitors Library
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Mitophagy Compound Library
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Bioactive Compound Library Max
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MCE Bioactive Compound Library
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Bioactive Compound Library
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Amino Acid Metabolism Compound Library
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Cell Proliferation Compound Library
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High-Throughput Bioactive Compound Library
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Posttranslational Modification Library
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Biological Activity
SENP1[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
>20 μM
Compound: 28
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Cytotoxicity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Cytotoxicity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
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[PMID: 34688014] |
SENP1-IN-3 improves the sensitivity of tumor cells to irradiation[1].
SENP1-IN-3 (0.7-20 μM; 72 hours)has cytotoxic for Hella cells with an IC50 of >20μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Hela cells
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Concentration:0.7 μM, 2.2 μM, 6.6 μM, 20 μM
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Incubation Time:72 hours
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Result:IC50>20 μM
Chemical Information
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CAS No. 2416910-59-1
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Appearance Solid
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Molecular Weight 582.86
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Formula C36H58N2O4
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Color White to off-white
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SMILES
CC1(C)[C@@H](OC(C)=O)CC[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@@](C(N(C)CC(NC)=O)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (171.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7157 mL | 8.5784 mL | 17.1568 mL | 42.8919 mL |
| 5 mM | 0.3431 mL | 1.7157 mL | 3.4314 mL | 8.5784 mL | |
| 10 mM | 0.1716 mL | 0.8578 mL | 1.7157 mL | 4.2892 mL | |
| 15 mM | 0.1144 mL | 0.5719 mL | 1.1438 mL | 2.8595 mL | |
| 20 mM | 0.0858 mL | 0.4289 mL | 0.8578 mL | 2.1446 mL | |
| 25 mM | 0.0686 mL | 0.3431 mL | 0.6863 mL | 1.7157 mL | |
| 30 mM | 0.0572 mL | 0.2859 mL | 0.5719 mL | 1.4297 mL | |
| 40 mM | 0.0429 mL | 0.2145 mL | 0.4289 mL | 1.0723 mL | |
| 50 mM | 0.0343 mL | 0.1716 mL | 0.3431 mL | 0.8578 mL | |
| 60 mM | 0.0286 mL | 0.1430 mL | 0.2859 mL | 0.7149 mL | |
| 80 mM | 0.0214 mL | 0.1072 mL | 0.2145 mL | 0.5361 mL | |
| 100 mM | 0.0172 mL | 0.0858 mL | 0.1716 mL | 0.4289 mL |
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