AXC-715 hydrochloride
Based on 1 Customer Validation
AXC-715 (T785) hydrochloride is a TLR7/TLR8 dual agonist. AXC-715 can be used for synthesis of antibody-adjuvant immunoconjugates, comprising an antibody construct that binds programmed death-ligand 1 (PD-L1) linked to one or more adjuvants.
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 2490497-93-1
- Formula: C18H26ClN5
- Molecular Weight:347.89
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
Immunology/Inflammation Compound Library
HY-L007
-
Anti-Cancer Compound Library
HY-L025
-
Small Molecule Immuno-Oncology Compound Library
HY-L031
-
Antioxidant Compound Library
HY-L037
-
Reprogramming Compound Library
HY-L039
-
Oxygen Sensing Compound Library
HY-L045
-
Pyroptosis Compound Library
HY-L059
-
Heterocyclic Compound Library
HY-L138
-
Pain-Related Compound Library
HY-L139
-
Membrane Protein-targeted Compound Library
HY-L149
-
Membrane Receptor-targeted Compound Library
HY-L150
-
Autoimmune Disease Compound Library
HY-L156
-
Immunopotentiator Compound Library
HY-L172
-
Multi-Target Compound Library
HY-L176
-
Radioprotector Library
HY-L178
-
MCE Bioactive Compound Library
HY-L001V
-
High-Throughput Bioactive Compound Library
HY-L205
-
Pattern Recognition Receptors Library
HY-L237
Biological Activity
|
TLR7 0.643 μM (EC50) |
TLR8 1.6 μM (EC50) |
AXC-715 hydrochloride (1 μM, 18 h) activates hTLR7 and hTLR8 with EC50s of 0.643 μM and 1.6 μM. AXC-715 causes human myeloid APCs stimulation[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:HCC1954 xenograft mouse models[3]
-
Dosage:5 mg/kg in form of AXC715-ISAC conjugation
-
Administration:ip, every 5 days for 6 doses
-
Result:Inhibited the tumor growth, increased the infiltration of myeloid APCs and CD8+ T cells in the tumor.
Chemical Information
-
CAS No. 2490497-93-1
-
Appearance Solid
-
Molecular Weight 347.89
-
Formula C18H26ClN5
-
Color Light yellow to yellow
-
SMILES
NCCCCN1C(CCCC)=NC2=C1C3=CC=CC=C3N=C2N.[H]Cl
-
Synonyms
T785 hydrochloride
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 50 mg/mL (143.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (274 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8745 mL | 14.3724 mL | 28.7447 mL | 71.8618 mL |
| 5 mM | 0.5749 mL | 2.8745 mL | 5.7489 mL | 14.3724 mL | |
| 10 mM | 0.2874 mL | 1.4372 mL | 2.8745 mL | 7.1862 mL | |
| 15 mM | 0.1916 mL | 0.9582 mL | 1.9163 mL | 4.7908 mL | |
| 20 mM | 0.1437 mL | 0.7186 mL | 1.4372 mL | 3.5931 mL | |
| 25 mM | 0.1150 mL | 0.5749 mL | 1.1498 mL | 2.8745 mL | |
| 30 mM | 0.0958 mL | 0.4791 mL | 0.9582 mL | 2.3954 mL | |
| 40 mM | 0.0719 mL | 0.3593 mL | 0.7186 mL | 1.7965 mL | |
| 50 mM | 0.0575 mL | 0.2874 mL | 0.5749 mL | 1.4372 mL | |
| 60 mM | 0.0479 mL | 0.2395 mL | 0.4791 mL | 1.1977 mL | |
| 80 mM | 0.0359 mL | 0.1797 mL | 0.3593 mL | 0.8983 mL | |
| 100 mM | 0.0287 mL | 0.1437 mL | 0.2874 mL | 0.7186 mL |
AXC-715 hydrochloride Related Classifications
HY-138139A Related Classifications
Powered by Bioz