AXC-715 trihydrochloride
Based on 1 Customer Validation
AXC-715 (T785) trihydrochloride is a TLR7/TLR8 dual agonist. AXC-715 trihydrochloride can be used for synthesis of antibody-adjuvant immunoconjugates, comprising an antibody construct that binds programmed death-ligand 1 (PD-L1) linked to one or more adjuvants.
For research use only. We do not sell to patients.
- Purity: 99.76%
- CAS No.: 2479276-17-8
- Formula: C18H28Cl3N5
- Molecular Weight:420.81
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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human TLR7 0.643 μM (EC50) |
TLR8 1.6 μM (EC50) |
AXC-715 trihydrochloride (1 μM, 18 h) activates hTLR7 and hTLR8 with EC50s of 0.643 μM and 1.6 μM. AXC-715 causes human myeloid APCs stimulation[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:HCC1954 xenograft mouse models[3]
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Dosage:5 mg/kg in form of AXC715-ISAC conjugation
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Administration:ip, every 5 days for 6 doses
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Result:Inhibited the tumor growth, increased the infiltration of myeloid APCs and CD8+ T cells in the tumor.
Chemical Information
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CAS No. 2479276-17-8
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Appearance Solid
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Molecular Weight 420.81
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Formula C18H28Cl3N5
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Color White to yellow
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SMILES
NC1=NC2=C(C=CC=C2)C3=C1N=C(CCCC)N3CCCCN.Cl.Cl.Cl
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Synonyms
T785 trihydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 125 mg/mL (297.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3764 mL | 11.8818 mL | 23.7637 mL | 59.4092 mL |
| 5 mM | 0.4753 mL | 2.3764 mL | 4.7527 mL | 11.8818 mL | |
| 10 mM | 0.2376 mL | 1.1882 mL | 2.3764 mL | 5.9409 mL | |
| 15 mM | 0.1584 mL | 0.7921 mL | 1.5842 mL | 3.9606 mL | |
| 20 mM | 0.1188 mL | 0.5941 mL | 1.1882 mL | 2.9705 mL | |
| 25 mM | 0.0951 mL | 0.4753 mL | 0.9505 mL | 2.3764 mL | |
| 30 mM | 0.0792 mL | 0.3961 mL | 0.7921 mL | 1.9803 mL | |
| 40 mM | 0.0594 mL | 0.2970 mL | 0.5941 mL | 1.4852 mL | |
| 50 mM | 0.0475 mL | 0.2376 mL | 0.4753 mL | 1.1882 mL | |
| 60 mM | 0.0396 mL | 0.1980 mL | 0.3961 mL | 0.9902 mL | |
| 80 mM | 0.0297 mL | 0.1485 mL | 0.2970 mL | 0.7426 mL | |
| 100 mM | 0.0238 mL | 0.1188 mL | 0.2376 mL | 0.5941 mL |
AXC-715 trihydrochloride Related Classifications
HY-138139B Related Classifications
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