2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. VH 101 phenol-alkylC4-amine dihydrochloride

VH 101 phenol-alkylC4-amine dihydrochloride is a von-Hippel-Lindau protein ligand (VHL), and incorporates an E3 ligase ligand plus an alkylC4 linker. VH 101 phenol-alkylC4-amine dihydrochloride can be used for PROTAC research extracted from patent WO2022051326A1.

For research use only. We do not sell to patients.

VH 101 phenol-alkylC4-amine dihydrochloride

VH 101 phenol-alkylC4-amine dihydrochloride Chemical Structure

CAS No. : 2564467-03-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
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VH 101 phenol-alkylC4-amine dihydrochloride Related Antibodies

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Description

VH 101 phenol-alkylC4-amine dihydrochloride is a von-Hippel-Lindau protein ligand (VHL), and incorporates an E3 ligase ligand plus an alkylC4 linker. VH 101 phenol-alkylC4-amine dihydrochloride can be used for PROTAC research extracted from patent WO2022051326A1.

Molecular Weight

676.67

Formula

C30H44Cl2FN5O5S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1(CC1)F)N[C@@H](C(C)(C)C)C(N2[C@@H](C[C@H](C2)O)C(NCC3=C(C=C(C4=C(C)N=CS4)C=C3)OCCCCN)=O)=O.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature, keep dry and cool

In solvent -80°C 1 year
-20°C 6 months
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (73.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4778 mL 7.3891 mL 14.7783 mL
5 mM 0.2956 mL 1.4778 mL 2.9557 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4778 mL 7.3891 mL 14.7783 mL 36.9456 mL
5 mM 0.2956 mL 1.4778 mL 2.9557 mL 7.3891 mL
10 mM 0.1478 mL 0.7389 mL 1.4778 mL 3.6946 mL
15 mM 0.0985 mL 0.4926 mL 0.9852 mL 2.4630 mL
20 mM 0.0739 mL 0.3695 mL 0.7389 mL 1.8473 mL
25 mM 0.0591 mL 0.2956 mL 0.5911 mL 1.4778 mL
30 mM 0.0493 mL 0.2463 mL 0.4926 mL 1.2315 mL
40 mM 0.0369 mL 0.1847 mL 0.3695 mL 0.9236 mL
50 mM 0.0296 mL 0.1478 mL 0.2956 mL 0.7389 mL
60 mM 0.0246 mL 0.1232 mL 0.2463 mL 0.6158 mL
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VH 101 phenol-alkylC4-amine dihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VH 101 phenol-alkylC4-amine2564467-03-2E3 Ligase Ligand-Linker ConjugatesE3 ligase ligandalkylC4 linkerPROTAC researchInhibitorinhibitorinhibit

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