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Cat. No.: HY-143729

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EGFR-IN-29

EGFR-IN-29 is a potent EGFR inhibitor, example J-022, extracted from Patent WO2021160087.

For research use only. We do not sell to patients.

CAS No.: 2682200-93-5
Formula: C₃₆H₄₆BrN₈O₂P
Molecular Weight:733.68

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

EGFR-IN-29 Chemical Structure

CAS No.: 2682200-93-5

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

EGFR-IN-29 is a potent EGFR inhibitor, example J-022, extracted from Patent WO2021160087^[1].

IC₅₀ & Target^[1]

EGFR^T790M

All EGFR Isoforms :

In Vitro

EGFR-IN-29 inhibits Ba/F3 cells with stable overexpression of △19del/T790M/C797S mutant genes, cells overexpressing EGFR WT and A431 carrying EGFR WT with IC₅₀ values of 6.8 nM, 151 nM and 1128 nM, respectively.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2682200-93-5
Molecular Weight 733.68
Formula C₃₆H₄₆BrN₈O₂P
SMILES

O=P(C)(C)C1=C2C=CC(C3CC3)=NC2=CC=C1NC4=NC(NC5=C(OC)C=C(N6CCC(CC6)N7CCN(CC7)C)C(C)=C5)=NC=C4Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xiangyong Liu. Quinolyl phosphine oxide compound, and composition and application thereof. Patent WO2021160087.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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EGFR-IN-29

All EGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

EGFR-IN-29 Related Classifications

HY-143729 Related Classifications