1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. PD-1-IN-17

PD-1-IN-17 

Cat. No.: HY-101097
Handling Instructions

PD-1-IN-17 is a programmed cell death- 1 (PD-1) inhibitor extracted from patent WO2015033301A1, Compound 12, inhibits 92% splenocyte proliferation at 100 nM.

For research use only. We do not sell to patients.

PD-1-IN-17 Chemical Structure

PD-1-IN-17 Chemical Structure

CAS No. : 1673560-66-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 605 In-stock
Estimated Time of Arrival: December 31
5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2750 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of PD-1-IN-17:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PD-1-IN-17 is a programmed cell death- 1 (PD-1) inhibitor extracted from patent WO2015033301A1, Compound 12, inhibits 92% splenocyte proliferation at 100 nM[1].

IC50 & Target

PD-1[1]

Molecular Weight

374.35

Formula

C₁₃H₂₂N₆O₇

CAS No.

1673560-66-1

SMILES

OC[[email protected]@H](C(O)=O)NC(N[[email protected]](C1=NN=C([[email protected]@H](N)[[email protected]](O)C)O1)CCC(N)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (333.91 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6713 mL 13.3565 mL 26.7130 mL
5 mM 0.5343 mL 2.6713 mL 5.3426 mL
10 mM 0.2671 mL 1.3356 mL 2.6713 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.56 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.56 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.56 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
PD-1-IN-17
Cat. No.:
HY-101097
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