NR1H4 activator 1
NR1H4 activator 1 is a potent and selective Famesoid X Receptor (FXR) agonist, extracted from patent WO2018152171A1, example 4. NR1H4 activator 1 shows strong FXR agonistic potency with a EC50 value of 1 nM in a Human FXR (NR1H4) Assay. NR1H4 activator 1 has the potential for treatment of gastrointestinal disease.
For research use only. We do not sell to patients.
- CAS No.: 2242855-68-9
- Formula: C34H53NO7S
- Molecular Weight:619.85
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
EC50: 1 nM (Famesoid X Receptor)[1]
NR1H4 activator 1 exhibits a EC50 value of 1 nM in a Human FXR (NR1H4) Assay. This assay is aim to determinate the ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2242855-68-9
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Molecular Weight 619.85
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Formula C34H53NO7S
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SMILES
C[C@@]12[C@@H]([C@H](C)COC(NS(=O)(C3=CC=C(OC(C)C)C=C3)=O)=O)CC[C@@]1([H])[C@]4([H])[C@H](O)[C@H](CC)[C@]5([H])C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NR1H4 activator 1 Related Classifications
HY-125996 Related Classifications
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