1. Epigenetics
  2. Histone Acetyltransferase
  3. P300/CBP-IN-5

P300/CBP-IN-5 

Cat. No.: HY-100132
Handling Instructions

P300/CBP-IN-5 is a potent p300/CBP histone acetyltransferase inhibitor extracted from patent WO2016044770A1, Example 715, has an IC50 of 18.8 nM.

For research use only. We do not sell to patients.

P300/CBP-IN-5 Chemical Structure

P300/CBP-IN-5 Chemical Structure

CAS No. : 1889284-33-6

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Description

P300/CBP-IN-5 is a potent p300/CBP histone acetyltransferase inhibitor extracted from patent WO2016044770A1, Example 715, has an IC50 of 18.8 nM[1].

IC50 & Target

IC50: 18.8 nM (p300/CBP)[1]

In Vitro

P300/CBP-IN-5 inhibits p300 LnCap-FGC cellls proliferation with an IC50 of 14.8 nM. P300/CBP-IN-5 inhibits H3K27Ac with an IC50 value of 4.6 nM in PC-3 cells[1].

In Vivo

The effect of P300/CBP-IN-5 (Example 715) on tumor growth is evaluated in subcutaneous, SuDHL-8 (B-cell lymphoma) and 22RV1 (prostate) xenograft tumors implanted in SCID female mice. Human cancer cells are inoculated subcutaneously into the right hind flank of female SCID mice on study day 0. Administration of P300/CBP-IN-5 (7.5 mg/kg/day) is initiated at the time of size match. P300/CBP-IN-5 induces significant tumor growth inhibition in multiple xenograft tumor models (the tumor growth inhibition of 62% in SuDHL-8 xenograft tumor model; 48% in 22RV1 xenograft tumor model)[1].

Molecular Weight

618.55

Formula

C₂₉H₂₇F₅N₆O₄

CAS No.

1889284-33-6

SMILES

O=C(CN(C1=O)C(N[[email protected]@]21C[[email protected]](C3=C2C=CC(C4=CN(N=C4)CC(NC)=O)=C3)F)=O)N([[email protected]](C(F)(F)F)C)CC5=CC=C(C=C5)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

P300/CBP-IN-5Histone AcetyltransferaseHATsHATInhibitorinhibitorinhibit

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