1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Kuraridine

Kuraridine 

Cat. No.: HY-121381
Handling Instructions

Kuraridine is a prenylated flavonol extract from the roots of Sophora flavescens. Kuraridine an inhibitory effect on cGMP specific phosphodiesterase type 5 (PDE5) and has an IC50 of 0.64 μM.

For research use only. We do not sell to patients.

Kuraridine Chemical Structure

Kuraridine Chemical Structure

CAS No. : 34981-25-4

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Description

Kuraridine is a prenylated flavonol extract from the roots of Sophora flavescens. Kuraridine an inhibitory effect on cGMP specific phosphodiesterase type 5 (PDE5) and has an IC50 of 0.64 μM[1].

IC50 & Target[1]

PDE5

0.64 μM (IC50)

In Vitro

Kuraridine shows potent inhibitory activity (IC50=0.64 μM) against cGMP PDE5 with 2.0- and 12.9-fold selectivity over PDE3 and PDE4, respectively[1].
Kuraridine induces pronounced chloride inward currents in the absence of GABA. Thecurrents does not exceed 10% of the maximal IGABA induced by a saturating GABA concentration (1 mM)[2].
Kuraridine induces a concentration–response curves for IGABA enhancement (EC50=4.0±2.4 μM) in Xenopus oocytes expressing GABAA receptors composed of α1, β2, and γ2S subunits[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

438.51

Formula

C₂₆H₃₀O₆

CAS No.

34981-25-4

SMILES

O=C(C1=C(OC)C=C(O)C(C[[email protected]](C(C)=C)C/C=C(C)\C)=C1O)/C=C/C2=CC=C(O)C=C2O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

KuraridinePhosphodiesterase (PDE)cGMPPDE5Sophora flavescensInhibitorinhibitorinhibit

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Kuraridine
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HY-121381
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