SENP1-IN-1
Based on 1 publication(s) in Google Scholar
SENP1-IN-1 is a specific deSUMOylation protease 1 (SENP1) inhibitor extracted from patent CN110627860, Compound 29. SENP1-IN-1 is developed for tumor radiosensitivity enhancement.
For research use only. We do not sell to patients.
- Purity: 99.55%
- CAS No.: 2416910-69-3
- Formula: C35H58N2O4
- Molecular Weight:570.85
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Metabolism/Protease Compound Library
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Publications Citing Use of MedChemExpress (MCE) SENP1-IN-1
More
Biological Activity
SENP1[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
>20 μM
Compound: 42
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Cytotoxicity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Cytotoxicity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
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[PMID: 34688014] |
SENP1-IN-1 may improve the sensitivity of tumor cells to irradiation[1].
SENP1-IN-1 (0.7-20 μM; 72 hours)has cytotoxic for Hella cells with an IC50 of >20μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Hela cells
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Concentration:0.7 μM, 2.2 μM, 6.6 μM, 20 μM
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Incubation Time:72 hours
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Result:IC50>20 μM
Chemical Information
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CAS No. 2416910-69-3
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Appearance Solid
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Molecular Weight 570.85
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Formula C35H58N2O4
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Color White to off-white
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SMILES
CC1(C)[C@@H](O)CC[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@@](C(NCC(N(CCO)C)=O)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Arch Med Res
Mechanism of SENP1-Mediated Regulation of Liver Sinusoidal Endothelial Cells to Promote Regeneration Via the HIF-1α Signaling Pathway. [Abstract]2025 Aug 22;56(8):103295. PMID: 40848695
Solvent & Solubility
DMSO : 100 mg/mL (175.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7518 mL | 8.7589 mL | 17.5177 mL | 43.7943 mL |
| 5 mM | 0.3504 mL | 1.7518 mL | 3.5035 mL | 8.7589 mL | |
| 10 mM | 0.1752 mL | 0.8759 mL | 1.7518 mL | 4.3794 mL | |
| 15 mM | 0.1168 mL | 0.5839 mL | 1.1678 mL | 2.9196 mL | |
| 20 mM | 0.0876 mL | 0.4379 mL | 0.8759 mL | 2.1897 mL | |
| 25 mM | 0.0701 mL | 0.3504 mL | 0.7007 mL | 1.7518 mL | |
| 30 mM | 0.0584 mL | 0.2920 mL | 0.5839 mL | 1.4598 mL | |
| 40 mM | 0.0438 mL | 0.2190 mL | 0.4379 mL | 1.0949 mL | |
| 50 mM | 0.0350 mL | 0.1752 mL | 0.3504 mL | 0.8759 mL | |
| 60 mM | 0.0292 mL | 0.1460 mL | 0.2920 mL | 0.7299 mL | |
| 80 mM | 0.0219 mL | 0.1095 mL | 0.2190 mL | 0.5474 mL | |
| 100 mM | 0.0175 mL | 0.0876 mL | 0.1752 mL | 0.4379 mL |
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