1. Protein Tyrosine Kinase/RTK
  2. VEGFR
  3. TIE-2/VEGFR-2 kinase-IN-1

TIE-2/VEGFR-2 kinase-IN-1 

Cat. No.: HY-112294
Handling Instructions

TIE-2/VEGFR-2 kinase-IN-1 is used for the synthesis of TIE-2 and/or VEGFR-2 inhibitors, extracted from patent WO2003022852, example 14. TIE-2/VEGFR-2 kinase-IN-1 is used for the study of diseases associated with inappropriate angiogenesis.

For research use only. We do not sell to patients.

TIE-2/VEGFR-2 kinase-IN-1 Chemical Structure

TIE-2/VEGFR-2 kinase-IN-1 Chemical Structure

CAS No. : 453590-24-4

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Description

TIE-2/VEGFR-2 kinase-IN-1 is used for the synthesis of TIE-2 and/or VEGFR-2 inhibitors, extracted from patent WO2003022852, example 14. TIE-2/VEGFR-2 kinase-IN-1 is used for the study of diseases associated with inappropriate angiogenesis[1].

In Vitro

Angiopoieten 1 is a ligand for the endotheiium-specific receptor tyrosine kinase, TIE-2 is a novel angiogenic factor[1].
Inhibition of TIE-2 is expected to serve to disrupt remodeling and maturation of new vasculature initiated by angiogenesis thereby disrupting the angiogenic process. Inhibition at the kinase domain binding site of VEGFR-2 would block phosphorylation of tyrosine residues and serve to disrupt initiation of angiogenesis.

Molecular Weight

241.25

Formula

C₁₃H₁₁N₃O₂

CAS No.

453590-24-4

SMILES

NC1=C2C(OC(C3=CC=C(OC)C=C3)=C2)=NC=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (20.73 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1451 mL 20.7254 mL 41.4508 mL
5 mM 0.8290 mL 4.1451 mL 8.2902 mL
10 mM 0.4145 mL 2.0725 mL 4.1451 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

TIE-2/VEGFR-2 kinase-IN-1VEGFRVascular endothelial growth factor receptorhyperproliferative diseasesDisorderangiogenesiscancertumorInhibitorinhibitorinhibit

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Product name:
TIE-2/VEGFR-2 kinase-IN-1
Cat. No.:
HY-112294
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