1. GPCR/G Protein
  2. Prostaglandin Receptor

AGN 210676 (Synonyms: Simenepag)

Cat. No.: HY-14898
Handling Instructions

AGN 210676 is a selective prostaglandin EP2 agonist extracted from patent US20070203222A1, Compound example 23, has an EC50 of 5 nM.

For research use only. We do not sell to patients.

AGN 210676 Chemical Structure

AGN 210676 Chemical Structure

CAS No. : 910562-15-1

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

AGN 210676 is a selective prostaglandin EP2 agonist extracted from patent US20070203222A1, Compound example 23, has an EC50 of 5 nM.

IC50 & Target[1]

EP2 Receptor

5 nM (EC50)

hEP3A Receptor

153 nM (EC50)

hDP Receptor

7749 nM (EC50)

In Vitro

AGN 210676 (Compound 23) also is a less potent agonist for recombinant human prostaglandin receptors hEP3A and hDP with EC50s of 153 nM and 7749 nM, respectively. AGN 210676 is useful for the treatment of glaucoma, ocular hypertension, inflammatory bowel disease, and the other diseases or conditions disclosed herein[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3172 mL 11.5861 mL 23.1723 mL
5 mM 0.4634 mL 2.3172 mL 4.6345 mL
10 mM 0.2317 mL 1.1586 mL 2.3172 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

431.55

Formula

C₂₃H₂₉NO₅S

CAS No.

910562-15-1

SMILES

O=C(C1=CC=C(COC[[email protected]@H](CC2)N(C3=CC=C([[email protected]@H](O)CCCCC)C=C3)C2=O)S1)O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
AGN 210676
Cat. No.:
HY-14898
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AGN 210676

Cat. No.: HY-14898