Glycolic acid oxidase inhibitor 1

Name: Glycolic acid oxidase inhibitor 1
Brand: MedChemExpress
SKU: HY-22166
Rating: 4.5 (0 reviews)

Art. -Nr.: HY-22166 Reinheit: 99.35%: Data Sheet
COA

SDS
Handling Instructions
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Technical Support

Glycolic acid oxidase inhibitor 1 is a glycolate oxidase inhibitor, extracted from patent EP0021228A1, in Table IV.

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Glycolic acid oxidase inhibitor 1 Chemische Struktur

CAS. Nr. : 77529-42-1

Größe	Verfügbarkeit	Menge

Kostenlose Probe (0.1 - 0.2 mg)	Jetzt bewerben
Kostenlose Probe (0.1 - 0.2 mg)	Jetzt bewerben
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
100 mg	Auf Lager	Estimated Time of Arrival: December 31
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500 mg	Angebot einholen

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Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

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Beschreibung

Glycolic acid oxidase inhibitor 1 is a glycolate oxidase inhibitor, extracted from patent EP0021228A1, in Table IV.

IC₅₀ & Target

Glycolate oxidase^[1]

In Vivo

Glycolic acid oxidase inhibitor 1 inhibits oxalate biosynthesis in isolated perfused rat liver. Glycolate oxidase inhibitors provide a specific approach to the prevention and treatment of calcium oxalate renal lithiasis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

344.16

Formel

C₁₆H₁₀BrNO₃

CAS. Nr.

77529-42-1

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C(C1=CC=C(C2=CC=C(Br)C=C2)C=C1)=C3O)NC3=O

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 137 mg/mL (398.07 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9056 mL	14.5281 mL	29.0563 mL
5 mM	0.5811 mL	2.9056 mL	5.8113 mL
10 mM	0.2906 mL	1.4528 mL	2.9056 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 99.35%

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Data Sheet (270 KB) SDS (251 KB)

COA (250 KB) RP-HPLC (260 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Cragoe Jr., Edward J, et al. 4-Substituted-3-hydroxy-3-pyrroline-2,5-dione compounds, process for their preparation and pharmaceutical compositions containing the same.EP0021228A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9056 mL	14.5281 mL	29.0563 mL	72.6406 mL
	5 mM	0.5811 mL	2.9056 mL	5.8113 mL	14.5281 mL
	10 mM	0.2906 mL	1.4528 mL	2.9056 mL	7.2641 mL
	15 mM	0.1937 mL	0.9685 mL	1.9371 mL	4.8427 mL
	20 mM	0.1453 mL	0.7264 mL	1.4528 mL	3.6320 mL
	25 mM	0.1162 mL	0.5811 mL	1.1623 mL	2.9056 mL
	30 mM	0.0969 mL	0.4843 mL	0.9685 mL	2.4214 mL
	40 mM	0.0726 mL	0.3632 mL	0.7264 mL	1.8160 mL
	50 mM	0.0581 mL	0.2906 mL	0.5811 mL	1.4528 mL
	60 mM	0.0484 mL	0.2421 mL	0.4843 mL	1.2107 mL
	80 mM	0.0363 mL	0.1816 mL	0.3632 mL	0.9080 mL
	100 mM	0.0291 mL	0.1453 mL	0.2906 mL	0.7264 mL