2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. VEGFR-2-IN-5

VEGFR-2-IN-5 is a VEGFR2 inhibitor extracted from patent WO2013055780A1, Page 69.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (VEGFR-2-IN-5 hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

VEGFR-2-IN-5 Chemical Structure

VEGFR-2-IN-5 Chemical Structure

CAS No. : 1430089-64-7

Size Price Stock
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 330 Ask For Quote & Lead Time
Solution
10 mM * 1 mL in DMSO USD 330 Ask For Quote & Lead Time
Solid
5 mg USD 300 Ask For Quote & Lead Time
10 mg USD 450 Ask For Quote & Lead Time
50 mg USD 1250 Ask For Quote & Lead Time
100 mg USD 1750 Ask For Quote & Lead Time

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Other In-stock Forms of VEGFR-2-IN-5:

Other Forms of VEGFR-2-IN-5:

VEGFR-2-IN-5 Related Antibodies

Top Publications Citing Use of Products

View All VEGFR Isoform Specific Products:

View All Isoforms
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • Biological Activity

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  • References

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Description

VEGFR-2-IN-5 is a VEGFR2 inhibitor extracted from patent WO2013055780A1, Page 69[1].

IC50 & Target[1]

VEGFR2

 

Molecular Weight

364.45

Formula

C19H24N8
CAS No.
Appearance

Solid

Color

White to gray

SMILES

NCCCNC1=CC=C(NC2=NC=CC(NC3=NNC(C4CC4)=C3)=N2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 46 mg/mL (126.22 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7439 mL 13.7193 mL 27.4386 mL
5 mM 0.5488 mL 2.7439 mL 5.4877 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7439 mL 13.7193 mL 27.4386 mL 68.5965 mL
5 mM 0.5488 mL 2.7439 mL 5.4877 mL 13.7193 mL
10 mM 0.2744 mL 1.3719 mL 2.7439 mL 6.8597 mL
15 mM 0.1829 mL 0.9146 mL 1.8292 mL 4.5731 mL
20 mM 0.1372 mL 0.6860 mL 1.3719 mL 3.4298 mL
25 mM 0.1098 mL 0.5488 mL 1.0975 mL 2.7439 mL
30 mM 0.0915 mL 0.4573 mL 0.9146 mL 2.2866 mL
40 mM 0.0686 mL 0.3430 mL 0.6860 mL 1.7149 mL
50 mM 0.0549 mL 0.2744 mL 0.5488 mL 1.3719 mL
60 mM 0.0457 mL 0.2287 mL 0.4573 mL 1.1433 mL
80 mM 0.0343 mL 0.1715 mL 0.3430 mL 0.8575 mL
100 mM 0.0274 mL 0.1372 mL 0.2744 mL 0.6860 mL
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VEGFR-2-IN-5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR-2-IN-51430089-64-7VEGFRVascular endothelial growth factor receptorInhibitorinhibitorinhibit

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