1. Protein Tyrosine Kinase/RTK
  2. VEGFR
  3. VEGFR-2-IN-5 hydrochloride

VEGFR-2-IN-5 hydrochloride is a VEGFR2 inhibitor extracted from patent WO2013055780A1, Page 69.

For research use only. We do not sell to patients.

VEGFR-2-IN-5 hydrochloride Chemical Structure

VEGFR-2-IN-5 hydrochloride Chemical Structure

CAS No. : 2700435-52-3

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO USD 330 In-stock
Solid
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10 mg USD 450 In-stock
50 mg USD 1250 In-stock
100 mg USD 1750 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

VEGFR-2-IN-5 hydrochloride is a VEGFR2 inhibitor extracted from patent WO2013055780A1, Page 69[1].

IC50 & Target

VEGFR2[1]

Molecular Weight

400.91

Formula

C19H25ClN8

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

NCCCNC1=CC=C(NC2=NC=CC(NC3=NNC(C4CC4)=C3)=N2)C=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 230 mg/mL (573.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (249.43 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4943 mL 12.4716 mL 24.9433 mL
5 mM 0.4989 mL 2.4943 mL 4.9887 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.4943 mL 12.4716 mL 24.9433 mL 62.3581 mL
5 mM 0.4989 mL 2.4943 mL 4.9887 mL 12.4716 mL
10 mM 0.2494 mL 1.2472 mL 2.4943 mL 6.2358 mL
15 mM 0.1663 mL 0.8314 mL 1.6629 mL 4.1572 mL
20 mM 0.1247 mL 0.6236 mL 1.2472 mL 3.1179 mL
25 mM 0.0998 mL 0.4989 mL 0.9977 mL 2.4943 mL
30 mM 0.0831 mL 0.4157 mL 0.8314 mL 2.0786 mL
40 mM 0.0624 mL 0.3118 mL 0.6236 mL 1.5590 mL
50 mM 0.0499 mL 0.2494 mL 0.4989 mL 1.2472 mL
60 mM 0.0416 mL 0.2079 mL 0.4157 mL 1.0393 mL
80 mM 0.0312 mL 0.1559 mL 0.3118 mL 0.7795 mL
100 mM 0.0249 mL 0.1247 mL 0.2494 mL 0.6236 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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VEGFR-2-IN-5 hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
VEGFR-2-IN-5 hydrochloride
Cat. No.:
HY-18625A
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