1. GPCR/G Protein
  2. LPL Receptor
  3. S1p receptor agonist 1

S1p receptor agonist 1 

Cat. No.: HY-101265 Purity: 99.97%
Handling Instructions

S1p receptor agonist 1 is a potent and orally active S1P receptor agonist, exhibits an activity of inducing S1P1 internalization (EC50=9.83 nM). S1p receptor agonist 1 has the potential for the study of arthritis and EAE (experimental autoimmune encephalitis). S1p receptor agonist 1 is extracted from patent WO2015039587A1, Compound 2.

For research use only. We do not sell to patients.

S1p receptor agonist 1 Chemical Structure

S1p receptor agonist 1 Chemical Structure

CAS No. : 1514888-56-2

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 378 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 378 In-stock
Estimated Time of Arrival: December 31
Solid
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

S1p receptor agonist 1 is a potent and orally active S1P receptor agonist, exhibits an activity of inducing S1P1 internalization (EC50=9.83 nM). S1p receptor agonist 1 has the potential for the study of arthritis and EAE (experimental autoimmune encephalitis). S1p receptor agonist 1 is extracted from patent WO2015039587A1, Compound 2[1].

IC50 & Target

EC50: 9.83 nM (S1P1 internalization)[1]

In Vivo

S1p receptor agonist 1 (oral administration; 0.01 mg/kg-1 mg/kg) at all dose is active, and only a dose of 0.01 mg/kg is required to observe a decrease in the number of peripheral blood lymphocytes by more than 50% and a decrease in the 1 mg/kg dose. Besides, this compound is lymphocyte-specific, which dose not significantly alter the number of peripheral monocytes and other white blood cells in SD rats[1].
S1p receptor agonist 1 (oral administration; 3 mg/kg; 12 days) is has been proved to block lymphocyte efflux. In the development of type II collagen-induced arthritis in rat model, compound 2 is effective in inhibiting the development of joint swelling in arthritis and joint structure destruction[1].
S1p receptor agonist 1 (oral administration; 0.3-1mg/kg; 30 days; once daily) inhibits the development of experimental autoimmune encephalitis (EAE) as a dose-dependent manner in mice model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lewis rats[1]
Dosage: 3 mg/kg
Administration: Oral administration
Result: Decreased the severity score of arthritis in the four-legged rats.
Animal Model: Female C57BL/6 mice[1] 
Dosage: 0.03, 0.1, and 1 mg/kg
Administration: Oral administration
Result: Decreased the severity score of EAE in MOG 35-55 induced mice.
Molecular Weight

409.45

Formula

C₂₃H₂₄FN₃O₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 6.8 mg/mL (16.61 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4423 mL 12.2115 mL 24.4230 mL
5 mM 0.4885 mL 2.4423 mL 4.8846 mL
10 mM 0.2442 mL 1.2212 mL 2.4423 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
S1p receptor agonist 1
Cat. No.:
HY-101265
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