MAX-40279 hydrochloride
Based on 1 publication(s) in Google Scholar
MAX-40279 hydrochloride is a dual and orally active inhibitor of FLT3 kinase and FGFR kinase. MAX-40279 hydrochloride is also effective against the FLT3 mutants such as FLT3D835Y, suggesting that it can overcome resistance to Quizartinib (HY-13001) and Sorafenib (HY-10201). MAX-40279 hydrochloride inhibits NDRG1 phosphorylation at Ser330 and suppresses endothelial-to-mesenchymal transition (EndMT). MAX-40279 hydrochloride can be used for the research of acute myelogenous leukemia (AML).
For research use only. We do not sell to patients.
- CAS No.: 2388506-51-0
- Formula: C22H24ClFN6OS
- Molecular Weight:474.98
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) MAX-40279 hydrochloride
More
Biological Activity
FLT3 and FGFR[1]
MAX-40279 (0.5-1 μM, 48 h) hydrochloride impedes EndMT by inhibiting NDRG1 phosphorylation at Ser-330 in HUVECs, MAECs, and MPLECs[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HUVECs
-
Concentration:0.5 and 1 μM
-
Incubation Time:48 h
-
Result:Attenuated migration of HUVEC induced by H2O2 and TGF-β.
-
Cell Line:HUVECs, MAECs, and MPLECs
-
Concentration:0.5 and 1 μM
-
Incubation Time:48 h
-
Result:Significantly inhibited the phosphorylation of NDRG1 at Ser-330.
Reduced the total protein level of NDRG1.
Inhibited the expression of mesenchymal markers such as ZEB1, α-SMA, Slug, Snail, and TAGLN.
MAX-40279 (12 mg/kg, p,o., twice daily for 21-28 days) hydrochloride significantly inhibited tumor growth in MV4-11 and KG-1 cells induced mice xenograft models[1].
MAX-40279 (7-15 mg/kg, p.o., twice daily for 2-3 weeks) hydrochloride significantly enhances the anti-PD-1 effect in mice breast cancer model[1].
MAX-40279 (p.o., single dose) hydrochloride has much higher drug concentration in bone marrow than in plasma in SD rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Micro patient-derived xenotransplantation model established in 5-week-old nu/nu mice[1]
-
Dosage:12 mg/kg
-
Administration:Oral administration (p.o.), once daily for 7 days
-
Result:Reduced the vitality of tumor cells.
The growth rates of tumour volume and weight were smaller but that the combined inhibition was more remarkable.
-
Animal Model:MV4-11 and KG-1 cells induced xenograft model established in immunodeficient mice[1]
-
Dosage:12 mg/kg
-
Administration:Oral administration (p.o.), once daily for 21-28 days
-
Result:Significantly inhibited tumor growth, with no significant weight loss or toxicity observed.
-
Animal Model:4T1 induced breast cancer model combination with anti-PD-1 established in mice[1]
-
Dosage:7, 10 and 15 mg/kg
-
Administration:Oral administration (p.o.), once daily for 2-3 weeks
-
Result:Significantly enhanced the efficacy of anti-PD-1 effect, and the combined treatment with anti-PD-1 antibodies yielded the best results.
Chemical Information
-
CAS No. 2388506-51-0
-
Molecular Weight 474.98
-
Formula C22H24ClFN6OS
-
SMILES
FC1=CC(OC)=C(C2=C(C)SC3=C2N=C(NC4=CN(C5CCNCC5)N=C4)N=C3)C=C1.[H]Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Theranostics
2025 Jan 1;15(2):745-765. PMID: 39744686
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz