2. Protein Tyrosine Kinase/RTK
  3. FLT3 FGFR
  4. MAX-40279 hemifumarate

MAX-40279 hemifumarate is a dual and potent inhibitor of FLT3 kinase and FGFR kinase. MAX-40279 hemifumarate has the potential for the research of acute myelogenous leukemia (AML) (extracted from patent WO2021180032).

For research use only. We do not sell to patients.

MAX-40279 hemifumarate Chemical Structure

MAX-40279 hemifumarate Chemical Structure

CAS No. : 2388506-43-0

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5 mg USD 300 In-stock
10 mg USD 480 In-stock
25 mg USD 950 In-stock
50 mg USD 1450 In-stock
100 mg USD 2250 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of MAX-40279 hemifumarate:

MAX-40279 hemifumarate Related Antibodies

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Description

MAX-40279 hemifumarate is a dual and potent inhibitor of FLT3 kinase and FGFR kinase. MAX-40279 hemifumarate has the potential for the research of acute myelogenous leukemia (AML) (extracted from patent WO2021180032)[1].

IC50 & Target

FLT3 and FGFR[1]
Clinical Trial
Molecular Weight

554.59

Formula

C22H23FN6OS.1/2C4H4O4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

OC(/C=C/C(O)=O)=O.CC1=C(C2=C(C=C(C=C2)F)OC)C3=NC(NC4=CN(C5CCNCC5)N=C4)=NC=C3S1.[1/2]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMF : 1.96 mg/mL (3.53 mM; ultrasonic and warming and adjust pH to 5 with HCl and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8031 mL 9.0157 mL 18.0313 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 1.8031 mL 9.0157 mL 18.0313 mL 45.0783 mL
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MAX-40279 hemifumarate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAX-40279 hemifumarate2388506-43-0FLT3FGFRCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Fibroblast growth factor receptordualacute myelogenous leukemiaInhibitorinhibitorinhibit

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MAX-40279 hemifumarate
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