RAF mutant-IN-1
RAF mutant-IN-1 is a RAF kinase inhibitor, extracted from patent WO2019107987A1, with IC50 values of 21 nM, 30 nM and 392 nM for C-RAF 340D/Y341D, B-RAFV600E and B-RAFWT, respectively.
For research use only. We do not sell to patients.
- CAS No.: 2340020-82-6
- Formula: C23H18Cl3FN6O2S
- Molecular Weight:567.85
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
IC50 & Target
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C-RAF 340D/Y341D 21 nM (IC50) |
B-RafV600E 30 nM (IC50) |
BRAFWT 392 nM (IC50) |
Chemical Information
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CAS No. 2340020-82-6
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Molecular Weight 567.85
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Formula C23H18Cl3FN6O2S
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SMILES
O=C(C1=CSC2=C(N)N=CN=C21)NC3=C(C)C=CC4=C3C=CN=C4NC5=CC=C(O)C(Cl)=C5F.[H]Cl.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)