2340020-82-6
2340020-82-6
Chemical Structure
RAF mutant-IN-1
- CAS No.: 2340020-82-6
- Formula:C23H18Cl3FN6O2S
- Molecular Weight:567.85
IUPAC Name: 4-amino-N-(1-((3-chloro-2-fluoro-4-hydroxyphenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide dihydrochloride
InChIKey: LUOSZUYSWJVQGN-UHFFFAOYSA-N
SMILES: O=C(C1=CSC2=C(N)N=CN=C21)NC3=C(C)C=CC4=C3C=CN=C4NC5=CC=C(O)C(Cl)=C5F.[H]Cl.[H]Cl
Biological Activity: RAF mutant-IN-1 is a RAF kinase inhibitor, extracted from patent WO2019107987A1, with IC50 values of 21 nM, 30 nM and 392 nM for C-RAF 340D/Y341D, B-RAFV600E and B-RAFWT, respectively[1].
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RAF mutant-IN-1 | RAF mutant-IN-1 is a RAF kinase inhibitor, extracted from patent WO2019107987A1, with IC50 values of 21 nM, 30 nM and 392 nM for C-RAF 340D/Y341D, B-RAFV600E and B-RAFWT, respectively. | |||||||||||||||||||||
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References
Keywords
