2. Natural Products
  3. Plants Flavonoids
  4. Moraceae Flavones
  5. Broussonetia papyrifera (Linnaeus) L'Heritier ex Ventenat
  6. 5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone

5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone 

Cat. No.: HY-N9174
Handling Instructions Technical Support

5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone is a natural product that can be extracted from B. papyrifera. 5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone has potent anti-proliferation effects on ER-positive breast cancer cells, with an IC50 value of 4.41 μM for MCF-7 cells. 5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone also reduces the tumor growth in the BCAP-37 xenograft.

For research use only. We do not sell to patients.

5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone

5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone Chemical Structure

CAS No. : 1353676-65-9

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5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone Related Antibodies

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Description

5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone is a natural product that can be extracted from B. papyrifera. 5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone has potent anti-proliferation effects on ER-positive breast cancer cells, with an IC50 value of 4.41 μM for MCF-7 cells. 5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone also reduces the tumor growth in the BCAP-37 xenograft[1].

Cellular Effect
Cell Line Type Value Description References
Hep 3B2 IC50
1.07 μM
Compound: 19
Cytotoxicity against human Hep3B cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
Cytotoxicity against human Hep3B cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
[PMID: 36549116]
HepG2 IC50
32.61 μM
Compound: 19
Cytotoxicity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
[PMID: 36549116]
Molecular Weight

452.50

Formula

C26H28O7
CAS No.
SMILES

O=C1C(OC)=C(C2=CC(C/C=C(C)\C)=C(O)C(O)=C2)OC3=C(C/C=C(C)\C)C(O)=CC(O)=C13
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone1353676-65-9OthersTumorbreast cancerER-positiveBCAP-37MCF-7Inhibitorinhibitorinhibit

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