Cat. No.: HY-N8377

Capsiate

4 Cited Publications

Customer Review

Based on 4 publication(s) in Google Scholar

Capsiate, as a capsaicin analogue extracted from a non-pungent cultivar of CH-19 sweet red pepper, is an orally active agonist of TRPV1.

For research use only. We do not sell to patients.

Purity: 99.85%
CAS No.: 205687-01-0
Formula: C₁₈H₂₆O₄
Molecular Weight:306.40

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Capsiate Chemical Structure

CAS No.: 205687-01-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (4)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Capsiate, as a capsaicin analogue extracted from a non-pungent cultivar of CH-19 sweet red pepper, is an orally active agonist of TRPV1^[1].

IC₅₀ & Target^[1]

TRPV1

All TRP Channel Isoforms :

In Vitro

Capsiate evokes current responses in HEK293 cells expressing TRPV1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Capsiate does not exhibit irritancy-related effects on the oral cavity or eye^[1].
Capsiate (0.03~0.54 mM; s.c.) induces nociceptive responses in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male ddY-strain mice (20–24 g) ^[1]
Dosage:

0.5 or 5 mM
Administration:

P.o.
Result:

Did not cause pungency-related behaviors.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 205687-01-0
Appearance Liquid (Density: 1.053 g/cm³)
Molecular Weight 306.40
Formula C₁₈H₂₆O₄
Color Colorless to light yellow
SMILES

CC(C)/C=C/CCCCC(OCC1=CC=C(O)C(OC)=C1)=O
Structure Classification
- Phenols
- Monophenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (4)

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Food Funct

A Capsicum annuum L. seed extract exerts anti-neuroexcitotoxicity in HT22 hippocampal neurons. [Abstract]

2024 Feb 19;15(4):2144-2153. PMID: 38305768
Microbiol Spectr

Capsiate attenuates atherosclerosis by activating Nrf2/GPX4 pathway and reshaping the intestinal microbiota in ApoE-/- mice. [Abstract]

2025 Apr;13(4):e0315524. PMID: 40029381
Futur J Pharm Sci

2026 Feb 3;12(1):15.
Letters in Applied NanoBioScience

2026 Jan.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (326.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.2637 mL

16.3185 mL

32.6371 mL

5 mM

0.6527 mL

3.2637 mL

6.5274 mL

10 mM

0.3264 mL

1.6319 mL

3.2637 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (420 KB)
- English - EN (420 KB)
- Français - FR (420 KB)
- Deutsch - DE (420 KB)
- Norwegian - NO (420 KB)
- Español - ES (420 KB)
- Swedish - SV (420 KB)
- Italian - IT (420 KB)
- Korean - KR (420 KB)
- Portuguese - PT (420 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Iida T, et al. TRPV1 activation and induction of nociceptive response by a non-pungent capsaicin-like compound, capsiate. Neuropharmacology. 2003;44(7):958-967. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.2637 mL	16.3185 mL	32.6371 mL	81.5927 mL
	5 mM	0.6527 mL	3.2637 mL	6.5274 mL	16.3185 mL
	10 mM	0.3264 mL	1.6319 mL	3.2637 mL	8.1593 mL
	15 mM	0.2176 mL	1.0879 mL	2.1758 mL	5.4395 mL
	20 mM	0.1632 mL	0.8159 mL	1.6319 mL	4.0796 mL
	25 mM	0.1305 mL	0.6527 mL	1.3055 mL	3.2637 mL
	30 mM	0.1088 mL	0.5440 mL	1.0879 mL	2.7198 mL
	40 mM	0.0816 mL	0.4080 mL	0.8159 mL	2.0398 mL
	50 mM	0.0653 mL	0.3264 mL	0.6527 mL	1.6319 mL
	60 mM	0.0544 mL	0.2720 mL	0.5440 mL	1.3599 mL
	80 mM	0.0408 mL	0.2040 mL	0.4080 mL	1.0199 mL
	100 mM	0.0326 mL	0.1632 mL	0.3264 mL	0.8159 mL

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Capsiate

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Publications Citing Use of MedChemExpress (MCE) Capsiate

All TRP Channel Isoforms

Biological Activity

Chemical Information

Publications (4)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Capsiate Related Classifications

HY-N8377 Related Classifications