ALK5-IN-8
Based on 1 Customer Validation
ALK5-IN-8 is a potent inhibitor of TGFβRI (ALK5). ALK5-IN-8 Inhibits the phosphorylation of ALK5 on its downstream signaling proteins (Smad2 or Smad3) by blocking the binding of TGFβRI to ligands, thereby affecting or blocking TGF-β signaling. ALK5-IN-8 has the potential for the research of various ALK5-mediated related diseases (extracted from patent WO2021190425A1, compound 1).
For research use only. We do not sell to patients.
- Purity: 98.21%
- CAS No.: 2705900-81-6
- Formula: C19H15FN4O2
- Molecular Weight:350.35
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Kinase Inhibitor Library
HY-L009
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TGF-beta/Smad Compound Library
HY-L018
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Anti-Cancer Compound Library
HY-L025
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Reprogramming Compound Library
HY-L039
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Anti-Pancreatic Cancer Compound Library
HY-L077
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Anti-Obesity Compound Library
HY-L087
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Angiogenesis-Related Compound Library
HY-L088
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Transcription Factor-Targeted Library
HY-L090
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Anti-Colorectal Cancer Compound Library
HY-L103
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Anti-Prostate Cancer Compound Library
HY-L124
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Anti-Pulmonary Fibrosis Compound Library
HY-L125
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Osteogenesis Compound Library
HY-L131
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Cancer Stem Cells Compound Library
HY-L135
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Heterocyclic Compound Library
HY-L138
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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Cytokine Inhibitors Library
HY-L161
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
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Anti-Fibrosis Compound Library
HY-L185
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Protein Kinase Compound Library
HY-L196
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
Biological Activity
Chemical Information
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CAS No. 2705900-81-6
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Appearance Solid
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Molecular Weight 350.35
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Formula C19H15FN4O2
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Color White to light yellow
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SMILES
O=C(C1=C2C=C(C3=CNN=C3C4=CC=C(F)C=C4)C=CN2N=C1)OCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (142.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8543 mL | 14.2714 mL | 28.5429 mL | 71.3572 mL |
| 5 mM | 0.5709 mL | 2.8543 mL | 5.7086 mL | 14.2714 mL | |
| 10 mM | 0.2854 mL | 1.4271 mL | 2.8543 mL | 7.1357 mL | |
| 15 mM | 0.1903 mL | 0.9514 mL | 1.9029 mL | 4.7571 mL | |
| 20 mM | 0.1427 mL | 0.7136 mL | 1.4271 mL | 3.5679 mL | |
| 25 mM | 0.1142 mL | 0.5709 mL | 1.1417 mL | 2.8543 mL | |
| 30 mM | 0.0951 mL | 0.4757 mL | 0.9514 mL | 2.3786 mL | |
| 40 mM | 0.0714 mL | 0.3568 mL | 0.7136 mL | 1.7839 mL | |
| 50 mM | 0.0571 mL | 0.2854 mL | 0.5709 mL | 1.4271 mL | |
| 60 mM | 0.0476 mL | 0.2379 mL | 0.4757 mL | 1.1893 mL | |
| 80 mM | 0.0357 mL | 0.1784 mL | 0.3568 mL | 0.8920 mL | |
| 100 mM | 0.0285 mL | 0.1427 mL | 0.2854 mL | 0.7136 mL |
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