ALK5-IN-8
Based on 1 Customer Validation
ALK5-IN-8 is a potent inhibitor of TGFβRI (ALK5). ALK5-IN-8 Inhibits the phosphorylation of ALK5 on its downstream signaling proteins (Smad2 or Smad3) by blocking the binding of TGFβRI to ligands, thereby affecting or blocking TGF-β signaling. ALK5-IN-8 has the potential for the research of various ALK5-mediated related diseases (extracted from patent WO2021190425A1, compound 1).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.21%
- CAS No.: 2705900-81-6
- 화학식: C19H15FN4O2
- 분자량:350.35
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 2705900-81-6
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Appearance Solid
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분자량 350.35
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화학식 C19H15FN4O2
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Color White to light yellow
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SMILES
O=C(C1=C2C=C(C3=CNN=C3C4=CC=C(F)C=C4)C=CN2N=C1)OCC
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 50 mg/mL (142.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8543 mL | 14.2714 mL | 28.5429 mL | 71.3572 mL |
| 5 mM | 0.5709 mL | 2.8543 mL | 5.7086 mL | 14.2714 mL | |
| 10 mM | 0.2854 mL | 1.4271 mL | 2.8543 mL | 7.1357 mL | |
| 15 mM | 0.1903 mL | 0.9514 mL | 1.9029 mL | 4.7571 mL | |
| 20 mM | 0.1427 mL | 0.7136 mL | 1.4271 mL | 3.5679 mL | |
| 25 mM | 0.1142 mL | 0.5709 mL | 1.1417 mL | 2.8543 mL | |
| 30 mM | 0.0951 mL | 0.4757 mL | 0.9514 mL | 2.3786 mL | |
| 40 mM | 0.0714 mL | 0.3568 mL | 0.7136 mL | 1.7839 mL | |
| 50 mM | 0.0571 mL | 0.2854 mL | 0.5709 mL | 1.4271 mL | |
| 60 mM | 0.0476 mL | 0.2379 mL | 0.4757 mL | 1.1893 mL | |
| 80 mM | 0.0357 mL | 0.1784 mL | 0.3568 mL | 0.8920 mL | |
| 100 mM | 0.0285 mL | 0.1427 mL | 0.2854 mL | 0.7136 mL |
ALK5-IN-8 Related Classifications
HY-144043 Related Classifications
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