2. TGF-beta/Smad
  3. TGF-β Receptor
  4. ALK5-IN-8

ALK5-IN-8 is a potent inhibitor of TGFβRI (ALK5). ALK5-IN-8 Inhibits the phosphorylation of ALK5 on its downstream signaling proteins (Smad2 or Smad3) by blocking the binding of TGFβRI to ligands, thereby affecting or blocking TGF-β signaling. ALK5-IN-8 has the potential for the research of various ALK5-mediated related diseases (extracted from patent WO2021190425A1, compound 1).

For research use only. We do not sell to patients.

ALK5-IN-8 Chemical Structure

ALK5-IN-8 Chemical Structure

CAS No. : 2705900-81-6

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 330 In-stock
Solution
10 mM * 1 mL in DMSO USD 330 In-stock
Solid
5 mg USD 300 In-stock
10 mg USD 450 In-stock
25 mg USD 950 In-stock
50 mg USD 1500 In-stock
100 mg USD 2400 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

ALK5-IN-8 Related Antibodies

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Description

ALK5-IN-8 is a potent inhibitor of TGFβRI (ALK5). ALK5-IN-8 Inhibits the phosphorylation of ALK5 on its downstream signaling proteins (Smad2 or Smad3) by blocking the binding of TGFβRI to ligands, thereby affecting or blocking TGF-β signaling. ALK5-IN-8 has the potential for the research of various ALK5-mediated related diseases (extracted from patent WO2021190425A1, compound 1)[1].

Molecular Weight

350.35

Formula

C19H15FN4O2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(C1=C2C=C(C3=CNN=C3C4=CC=C(F)C=C4)C=CN2N=C1)OCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (142.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8543 mL 14.2714 mL 28.5429 mL
5 mM 0.5709 mL 2.8543 mL 5.7086 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8543 mL 14.2714 mL 28.5429 mL 71.3572 mL
5 mM 0.5709 mL 2.8543 mL 5.7086 mL 14.2714 mL
10 mM 0.2854 mL 1.4271 mL 2.8543 mL 7.1357 mL
15 mM 0.1903 mL 0.9514 mL 1.9029 mL 4.7571 mL
20 mM 0.1427 mL 0.7136 mL 1.4271 mL 3.5679 mL
25 mM 0.1142 mL 0.5709 mL 1.1417 mL 2.8543 mL
30 mM 0.0951 mL 0.4757 mL 0.9514 mL 2.3786 mL
40 mM 0.0714 mL 0.3568 mL 0.7136 mL 1.7839 mL
50 mM 0.0571 mL 0.2854 mL 0.5709 mL 1.4271 mL
60 mM 0.0476 mL 0.2379 mL 0.4757 mL 1.1893 mL
80 mM 0.0357 mL 0.1784 mL 0.3568 mL 0.8920 mL
100 mM 0.0285 mL 0.1427 mL 0.2854 mL 0.7136 mL
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ALK5-IN-8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALK5-IN-82705900-81-6TGF-β ReceptorTransforming growth factor beta receptorsTGFβRIALK5phosphorylationSmad2Smad3Inhibitorinhibitorinhibit

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