Complement factor D-IN-2

Name: Complement factor D-IN-2
Brand: MedChemExpress
SKU: HY-138281
Rating: 4.5 (1 reviews)

Cat. No.: HY-138281 Purity: 99.33%: FAQs
Data Sheet SDS COA Handling Instructions

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Complement factor D-IN-2 is an inhibitor of complement factor D extracted from patent WO2015130838A1, compound 190. Complement factor D-IN-2 targets factor D and inhibits the complement cascade at an early and essential point in the alternative complement pathway. Complement factor D-IN-2 can be used for the research of autoimmune diseases.

For research use only. We do not sell to patients.

Complement factor D-IN-2 Chemical Structure

CAS No. : 1903742-34-6

Size	Price	Stock	Quantity
1 mg	USD 338	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 710	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1120	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1800	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2900	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 4650	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

complement factor D^[1]

In Vitro

Complement factor D-IN-2 reduces the excessive activation of complement factor D^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

574.43

Formula

C₂₇H₂₄BrN₇O₃

CAS No.

1903742-34-6

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1N(C(CN2N=C(C(C)=O)C3=C2C=CC(C4=CN=C(C)N=C4)=C3)=O)[C@]5([H])C[C@]5([H])C1)NC6=NC(Br)=CC=C6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (174.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7409 mL	8.7043 mL	17.4086 mL
5 mM	0.3482 mL	1.7409 mL	3.4817 mL
10 mM	0.1741 mL	0.8704 mL	1.7409 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.33%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (254 KB) HNMR (282 KB) LCMS (258 KB)

Handling Instructions (2659 KB)

References

[1]. GADHACHANDA VR, et, al. Aryl, heteroaryl, and heterocyclic compounds for treatment of complement mediated disorders. WO2015130838A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7409 mL	8.7043 mL	17.4086 mL	43.5214 mL
	5 mM	0.3482 mL	1.7409 mL	3.4817 mL	8.7043 mL
	10 mM	0.1741 mL	0.8704 mL	1.7409 mL	4.3521 mL
	15 mM	0.1161 mL	0.5803 mL	1.1606 mL	2.9014 mL
	20 mM	0.0870 mL	0.4352 mL	0.8704 mL	2.1761 mL
	25 mM	0.0696 mL	0.3482 mL	0.6963 mL	1.7409 mL
	30 mM	0.0580 mL	0.2901 mL	0.5803 mL	1.4507 mL
	40 mM	0.0435 mL	0.2176 mL	0.4352 mL	1.0880 mL
	50 mM	0.0348 mL	0.1741 mL	0.3482 mL	0.8704 mL
	60 mM	0.0290 mL	0.1451 mL	0.2901 mL	0.7254 mL
	80 mM	0.0218 mL	0.1088 mL	0.2176 mL	0.5440 mL
	100 mM	0.0174 mL	0.0870 mL	0.1741 mL	0.4352 mL