2. Apoptosis Metabolic Enzyme/Protease Anti-infection Cytoskeleton
  3. Apoptosis Endogenous Metabolite Fungal Parasite Arp2/3 Complex
  4. Chaetoglobosin A

Chaetoglobosin A is a secondary metabolite and nematicide. Chaetoglobosin A is produced by Penicillium aquamarinium. Chaetoglobosin A targets Filamentous actin in cells, thereby inducing cell cycle arrest, and inhibiting membrane ruffle formation and cell migration. Chaetoglobosin A preferentially induces Apoptosis in chronic lymphocytic leukemia cells. Chaetoglobosin A induces dose- and time-dependent death in J2 larvae of the southern root-knot nematode (Meloidogyne incognita). Chaetoglobosin A can be used in studies related to root-knot nematode disease and chronic lymphocytic leukemia.

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Chaetoglobosin A

Chaetoglobosin A Chemical Structure

CAS No. : 50335-03-0

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Chaetoglobosin A Related Antibodies

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Description

Chaetoglobosin A is a secondary metabolite and nematicide. Chaetoglobosin A is produced by Penicillium aquamarinium. Chaetoglobosin A targets Filamentous actin in cells, thereby inducing cell cycle arrest, and inhibiting membrane ruffle formation and cell migration. Chaetoglobosin A preferentially induces Apoptosis in chronic lymphocytic leukemia cells. Chaetoglobosin A induces dose- and time-dependent death in J2 larvae of the southern root-knot nematode (Meloidogyne incognita). Chaetoglobosin A can be used in studies related to root-knot nematode disease and chronic lymphocytic leukemia[1][2].

IC50 & Target[1]

Fungal Metabolite

 

Cellular Effect
Cell Line Type Value Description References
HeLa IC50
3.2 μg/mL
Compound: 4
Cytotoxicity against human HeLa cells
Cytotoxicity against human HeLa cells
[PMID: 15497948]
HepG2 IC50
6.3 μM
Compound: 2
Cytotoxicity against human HepG2 cells by MTT assay
Cytotoxicity against human HepG2 cells by MTT assay
[PMID: 27759375]
P388 IC50
1.94 μg/mL
Compound: 4
Cytotoxicity against mouse P388 cells
Cytotoxicity against mouse P388 cells
[PMID: 15497948]
In Vitro

Chaetoglobosin A (3-300 μg/mL; 3-14 days) inhibits egg hatching of Meloidogyne incognita; after 14 days of exposure, the hatching inhibition rate reaches 63.7% at the concentration of 30 μg/mL[1].
Chaetoglobosin A (3-300 μg/mL; 24-72 h) induces dose- and time-dependent death in J2 larvae of Meloidogyne incognita, with an LC50 of 77.0 μg/mL after 72 h of exposure[1].
Chaetoglobosin A (1-10 μM; 24-48 h) preferentially reduces the viability of primary chronic lymphocytic leukemia (CLL) cells (median LD50 = 2.8 μM) and induces caspase-dependent apoptosis, with minimal effects on normal B cells or T cells, compared to PBMCs from healthy donors and non-malignant stromal/fibroblast cells[2].
Chaetoglobosin A (1 μM) inhibits SDF1α-induced migration of primary CLL cells at a concentration of 1 μM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chaetoglobosin A Related Antibodies
In Vivo

Chaetoglobosin A targets lymphocytes and highly proliferating cells in vivo, inducing spleen and thymus necrosis and spermatocyte degeneration in mice and rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

528.64

Formula

C32H36N2O5
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(/C=C/C1=O)[C@H](O)/C(C)=C/[C@@H](C)C/C=C/[C@]2([H])[C@]31C(N[C@@H](CC4=CNC5=C4C=CC=C5)[C@]3([H])[C@H](C)[C@]6(C)[C@@]2([H])O6)=O
Structure Classification
Initial Source

Penicillium aquamarinium
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 10 mg/mL (18.92 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8916 mL 9.4582 mL 18.9165 mL
5 mM 0.3783 mL 1.8916 mL 3.7833 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.07%

SDS (394 KB)

COA (262 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8916 mL 9.4582 mL 18.9165 mL 47.2912 mL
5 mM 0.3783 mL 1.8916 mL 3.7833 mL 9.4582 mL
10 mM 0.1892 mL 0.9458 mL 1.8916 mL 4.7291 mL
15 mM 0.1261 mL 0.6305 mL 1.2611 mL 3.1527 mL
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Chaetoglobosin A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chaetoglobosin A50335-03-0ApoptosisEndogenous MetaboliteFungalParasiteArp2/3 ComplexActin-related protein 2/3 complexMeloidogyne incognitaF-actinprimary CLL cellsPI3K inhibitorschronic lymphocytic leukemia cellsJEKO-1 cellsG-actinMEC-1 CLL cellsactin filamentBTK inhibitorsInhibitorinhibitorinhibit

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