Chaetoglobosin A
Based on 1 Customer Validation
Chaetoglobosin A is a secondary metabolite and nematicide. Chaetoglobosin A is produced by Penicillium aquamarinium. Chaetoglobosin A targets Filamentous actin in cells, thereby inducing cell cycle arrest, and inhibiting membrane ruffle formation and cell migration. Chaetoglobosin A preferentially induces Apoptosis in chronic lymphocytic leukemia cells. Chaetoglobosin A induces dose- and time-dependent death in J2 larvae of the southern root-knot nematode (Meloidogyne incognita). Chaetoglobosin A can be used in studies related to root-knot nematode disease and chronic lymphocytic leukemia.
For research use only. We do not sell to patients.
- Purity: 99.07%
- CAS No.: 50335-03-0
- Formula: C32H36N2O5
- Molecular Weight:528.64
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Fungal Metabolite |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
3.2 μg/mL
Compound: 4
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Cytotoxicity against human HeLa cells
Cytotoxicity against human HeLa cells
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[PMID: 15497948] |
| HepG2 | IC50 |
6.3 μM
Compound: 2
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Cytotoxicity against human HepG2 cells by MTT assay
Cytotoxicity against human HepG2 cells by MTT assay
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[PMID: 27759375] |
| P388 | IC50 |
1.94 μg/mL
Compound: 4
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Cytotoxicity against mouse P388 cells
Cytotoxicity against mouse P388 cells
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[PMID: 15497948] |
Chaetoglobosin A (3-300 μg/mL; 3-14 days) inhibits egg hatching of Meloidogyne incognita; after 14 days of exposure, the hatching inhibition rate reaches 63.7% at the concentration of 30 μg/mL[1].
Chaetoglobosin A (3-300 μg/mL; 24-72 h) induces dose- and time-dependent death in J2 larvae of Meloidogyne incognita, with an LC50 of 77.0 μg/mL after 72 h of exposure[1].
Chaetoglobosin A (1-10 μM; 24-48 h) preferentially reduces the viability of primary chronic lymphocytic leukemia (CLL) cells (median LD50 = 2.8 μM) and induces caspase-dependent apoptosis, with minimal effects on normal B cells or T cells, compared to PBMCs from healthy donors and non-malignant stromal/fibroblast cells[2].
Chaetoglobosin A (1 μM) inhibits SDF1α-induced migration of primary CLL cells at a concentration of 1 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 50335-03-0
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Appearance Solid
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Molecular Weight 528.64
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Formula C32H36N2O5
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Color White to light yellow
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SMILES
O=C(/C=C/C1=O)[C@H](O)/C(C)=C/[C@@H](C)C/C=C/[C@]2([H])[C@]31C(N[C@@H](CC4=CNC5=C4C=CC=C5)[C@]3([H])[C@H](C)[C@]6(C)[C@@]2([H])O6)=O
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Structure Classification
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Initial Source
Penicillium aquamarinium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 10 mg/mL (18.92 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (282 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Hu Y, et al. Nematicidal activity of chaetoglobosin A poduced by Chaetomium globosum NK102 against Meloidogyne incognita. J Agric Food Chem. 2013;61(1):41-46. [Content Brief]
[2]. Knudsen PB, et al. Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton. Leukemia. 2014;28(6):1289-1298. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.8916 mL | 9.4582 mL | 18.9165 mL | 47.2912 mL |
| 5 mM | 0.3783 mL | 1.8916 mL | 3.7833 mL | 9.4582 mL | |
| 10 mM | 0.1892 mL | 0.9458 mL | 1.8916 mL | 4.7291 mL | |
| 15 mM | 0.1261 mL | 0.6305 mL | 1.2611 mL | 3.1527 mL |
Chaetoglobosin A Related Classifications
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