2. Apoptosis Metabolic Enzyme/Protease Anti-infection Cytoskeleton
  3. Apoptosis Endogenous Metabolite Fungal Parasite Arp2/3 Complex
  4. Chaetoglobosin A

Chaetoglobosin A is a secondary metabolite and nematicide. Chaetoglobosin A is produced by Penicillium aquamarinium. Chaetoglobosin A targets Filamentous actin in cells, thereby inducing cell cycle arrest, and inhibiting membrane ruffle formation and cell migration. Chaetoglobosin A preferentially induces Apoptosis in chronic lymphocytic leukemia cells. Chaetoglobosin A induces dose- and time-dependent death in J2 larvae of the southern root-knot nematode (Meloidogyne incognita). Chaetoglobosin A can be used in studies related to root-knot nematode disease and chronic lymphocytic leukemia.

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Chaetoglobosin A

Chaetoglobosin A Chemical Structure

CAS No. : 50335-03-0

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Based on 1 publication(s) in Google Scholar

Chaetoglobosin A Related Antibodies

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Description

Chaetoglobosin A is a secondary metabolite and nematicide. Chaetoglobosin A is produced by Penicillium aquamarinium. Chaetoglobosin A targets Filamentous actin in cells, thereby inducing cell cycle arrest, and inhibiting membrane ruffle formation and cell migration. Chaetoglobosin A preferentially induces Apoptosis in chronic lymphocytic leukemia cells. Chaetoglobosin A induces dose- and time-dependent death in J2 larvae of the southern root-knot nematode (Meloidogyne incognita). Chaetoglobosin A can be used in studies related to root-knot nematode disease and chronic lymphocytic leukemia[1][2].

IC50 & Target[1]

Fungal Metabolite

 

Cellular Effect
Cell Line Type Value Description References
HeLa IC50
3.2 μg/mL
Compound: 4
Cytotoxicity against human HeLa cells
Cytotoxicity against human HeLa cells
[PMID: 15497948]
HepG2 IC50
6.3 μM
Compound: 2
Cytotoxicity against human HepG2 cells by MTT assay
Cytotoxicity against human HepG2 cells by MTT assay
[PMID: 27759375]
P388 IC50
1.94 μg/mL
Compound: 4
Cytotoxicity against mouse P388 cells
Cytotoxicity against mouse P388 cells
[PMID: 15497948]
In Vitro

Chaetoglobosin A (3-300 μg/mL; 3-14 days) inhibits egg hatching of Meloidogyne incognita; after 14 days of exposure, the hatching inhibition rate reaches 63.7% at the concentration of 30 μg/mL[1].
Chaetoglobosin A (3-300 μg/mL; 24-72 h) induces dose- and time-dependent death in J2 larvae of Meloidogyne incognita, with an LC50 of 77.0 μg/mL after 72 h of exposure[1].
Chaetoglobosin A (1-10 μM; 24-48 h) preferentially reduces the viability of primary chronic lymphocytic leukemia (CLL) cells (median LD50 = 2.8 μM) and induces caspase-dependent apoptosis, with minimal effects on normal B cells or T cells, compared to PBMCs from healthy donors and non-malignant stromal/fibroblast cells[2].
Chaetoglobosin A (1 μM) inhibits SDF1α-induced migration of primary CLL cells at a concentration of 1 μM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chaetoglobosin A Related Antibodies
In Vivo

Chaetoglobosin A targets lymphocytes and highly proliferating cells in vivo, inducing spleen and thymus necrosis and spermatocyte degeneration in mice and rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

528.64

Formula

C32H36N2O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(/C=C/C1=O)[C@H](O)/C(C)=C/[C@@H](C)C/C=C/[C@]2([H])[C@]31C(N[C@@H](CC4=CNC5=C4C=CC=C5)[C@]3([H])[C@H](C)[C@]6(C)[C@@]2([H])O6)=O
Structure Classification
Initial Source

Penicillium aquamarinium
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 10 mg/mL (18.92 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8916 mL 9.4582 mL 18.9165 mL
5 mM 0.3783 mL 1.8916 mL 3.7833 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.07%

SDS (394 KB)

COA (262 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8916 mL 9.4582 mL 18.9165 mL 47.2912 mL
5 mM 0.3783 mL 1.8916 mL 3.7833 mL 9.4582 mL
10 mM 0.1892 mL 0.9458 mL 1.8916 mL 4.7291 mL
15 mM 0.1261 mL 0.6305 mL 1.2611 mL 3.1527 mL
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Chaetoglobosin A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chaetoglobosin A50335-03-0ApoptosisEndogenous MetaboliteFungalParasiteArp2/3 ComplexActin-related protein 2/3 complexMeloidogyne incognitaF-actinprimary CLL cellsPI3K inhibitorschronic lymphocytic leukemia cellsJEKO-1 cellsG-actinMEC-1 CLL cellsactin filamentBTK inhibitorsInhibitorinhibitorinhibit

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