1. Cell Cycle/DNA Damage
    TGF-beta/Smad
    Stem Cell/Wnt
  2. ROCK

ROCK2-IN-2 

Cat. No.: HY-103620
Handling Instructions

ROCK2-IN-2 is a selective ROCK2 inhibitor extracted from patent US20180093978A1, Compound A-30, has an IC50 of <1 μM.

For research use only. We do not sell to patients.

ROCK2-IN-2 Chemical Structure

ROCK2-IN-2 Chemical Structure

CAS No. : 1995065-79-6

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

ROCK2-IN-2 is a selective ROCK2 inhibitor extracted from patent US20180093978A1, Compound A-30, has an IC50 of <1 μM.

IC50 & Target[1]

ROCK2

1 μM (IC50)

In Vitro

Rho-associated protein kinase (ROCK) is a member of the serine-threonine protein kinase family. ROCK, which exists in two isoforms, ROCK1 and ROCK2, is an effector molecule of RhoA, and the RhoA/ROCK signaling pathway is involved in a number of cellular functions, which include, for example, actin organization, cell adhesion, cell migration, and cytokinesis. In addition, the RhoA/ROCK signaling pathway is involved in regulating smooth muscle contraction. Inhibitors of ROCK have been reported to be useful for treating multiple medical disorders, such as fibrosis, inflammatory disorders, autoimmune disorders, and cardiovascular disorders[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7748 mL 13.8739 mL 27.7477 mL
5 mM 0.5550 mL 2.7748 mL 5.5495 mL
10 mM 0.2775 mL 1.3874 mL 2.7748 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

360.39

Formula

C₁₈H₁₂N₆OS

CAS No.

1995065-79-6

SMILES

C12=CC(NC3=NN=C(C4=CC(C5=NC=CO5)=CC=C4)S3)=CC=C1NN=C2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
ROCK2-IN-2
Cat. No.:
HY-103620
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ROCK2-IN-2

Cat. No.: HY-103620