2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. CRTh2 antagonist 2

CRTh2 antagonist 2 is selective and potent CRTH2 antagonist extracted from patent US20140148470A1, compound Example 1, has an IC50 of ≤10 nM. CRTh2 antagonist 2 can be used in research of androgenic alopecia.

For research use only. We do not sell to patients.

CRTh2 antagonist 2 Chemical Structure

CRTh2 antagonist 2 Chemical Structure

CAS No. : 780763-95-3

Size Price Stock Quantity
1 mg USD 298 In-stock
5 mg   Get quote  
10 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

CRTh2 antagonist 2 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CRTh2 antagonist 2 is selective and potent CRTH2 antagonist extracted from patent US20140148470A1, compound Example 1, has an IC50 of ≤10 nM. CRTh2 antagonist 2 can be used in research of androgenic alopecia[1].

IC50 & Target

IC50: ≤10 nM (CRTh2)[1]
In Vitro

CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells) protein, also known as GPR44, is a G-protein coupled receptor (GPCR) which is amongst other ligands most strongly activated by prostaglandin D2 (PGD2). PGD2 is a product of prostaglandin D2 synthase (PTGDS)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CRTh2 antagonist 2 Related Antibodies
Molecular Weight

474.94

Formula

C26H23ClN4O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(O)CC1=C(N(C)C)N=C(CC2=CC=C(NC(C3=CC=C4C=CC=CC4=C3)=O)C=C2)N=C1Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (263.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1055 mL 10.5276 mL 21.0553 mL
5 mM 0.4211 mL 2.1055 mL 4.2111 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1055 mL 10.5276 mL 21.0553 mL 52.6382 mL
5 mM 0.4211 mL 2.1055 mL 4.2111 mL 10.5276 mL
10 mM 0.2106 mL 1.0528 mL 2.1055 mL 5.2638 mL
15 mM 0.1404 mL 0.7018 mL 1.4037 mL 3.5092 mL
20 mM 0.1053 mL 0.5264 mL 1.0528 mL 2.6319 mL
25 mM 0.0842 mL 0.4211 mL 0.8422 mL 2.1055 mL
30 mM 0.0702 mL 0.3509 mL 0.7018 mL 1.7546 mL
40 mM 0.0526 mL 0.2632 mL 0.5264 mL 1.3160 mL
50 mM 0.0421 mL 0.2106 mL 0.4211 mL 1.0528 mL
60 mM 0.0351 mL 0.1755 mL 0.3509 mL 0.8773 mL
80 mM 0.0263 mL 0.1316 mL 0.2632 mL 0.6580 mL
100 mM 0.0211 mL 0.1053 mL 0.2106 mL 0.5264 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

CRTh2 antagonist 2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRTh2 antagonist 2780763-95-3Prostaglandin ReceptorCRTH2androgenicalopeciahairlossInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
CRTh2 antagonist 2
Cat. No.:
HY-125970
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.