1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. CRTh2 antagonist 2

CRTh2 antagonist 2 

Cat. No.: HY-125970
Handling Instructions

CRTh2 antagonist 2 is selective and potent CRTH2 antagonist extracted from patent US20140148470A1, compound Example 1, has an IC50 of ≤10 nM. CRTh2 antagonist 2 can be used in research of androgenic alopecia.

For research use only. We do not sell to patients.

CRTh2 antagonist 2 Chemical Structure

CRTh2 antagonist 2 Chemical Structure

CAS No. : 780763-95-3

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Description

CRTh2 antagonist 2 is selective and potent CRTH2 antagonist extracted from patent US20140148470A1, compound Example 1, has an IC50 of ≤10 nM. CRTh2 antagonist 2 can be used in research of androgenic alopecia[1].

IC50 & Target

IC50: ≤10 nM (CRTh2)[1]

In Vitro

CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells) protein, also known as GPR44, is a G-protein coupled receptor (GPCR) which is amongst other ligands most strongly activated by prostaglandin D2 (PGD2). PGD2 is a product of prostaglandin D2 synthase (PTGDS)[1].

Molecular Weight

474.94

Formula

C₂₆H₂₃ClN₄O₃

CAS No.

780763-95-3

SMILES

O=C(O)CC1=C(N(C)C)N=C(CC2=CC=C(NC(C3=CC=C4C=CC=CC4=C3)=O)C=C2)N=C1Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

CRTh2 antagonist 2Prostaglandin ReceptorCRTH2androgenicalopeciahairlossInhibitorinhibitorinhibit

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CRTh2 antagonist 2
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