CRTh2 antagonist 2
Based on 1 Customer Validation
CRTh2 antagonist 2 is selective and potent CRTH2 antagonist extracted from patent US20140148470A1, compound Example 1, has an IC50 of ≤10 nM. CRTh2 antagonist 2 can be used in research of androgenic alopecia.
For research use only. We do not sell to patients.
- Purity: 99.78%
- CAS No.: 780763-95-3
- Formula: C26H23ClN4O3
- Molecular Weight:474.94
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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DP |
CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells) protein, also known as GPR44, is a G-protein coupled receptor (GPCR) which is amongst other ligands most strongly activated by prostaglandin D2 (PGD2). PGD2 is a product of prostaglandin D2 synthase (PTGDS)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 780763-95-3
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Appearance Solid
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Molecular Weight 474.94
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Formula C26H23ClN4O3
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Color Off-white to light yellow
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SMILES
O=C(O)CC1=C(N(C)C)N=C(CC2=CC=C(NC(C3=CC=C4C=CC=CC4=C3)=O)C=C2)N=C1Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (263.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1055 mL | 10.5276 mL | 21.0553 mL | 52.6382 mL |
| 5 mM | 0.4211 mL | 2.1055 mL | 4.2111 mL | 10.5276 mL | |
| 10 mM | 0.2106 mL | 1.0528 mL | 2.1055 mL | 5.2638 mL | |
| 15 mM | 0.1404 mL | 0.7018 mL | 1.4037 mL | 3.5092 mL | |
| 20 mM | 0.1053 mL | 0.5264 mL | 1.0528 mL | 2.6319 mL | |
| 25 mM | 0.0842 mL | 0.4211 mL | 0.8422 mL | 2.1055 mL | |
| 30 mM | 0.0702 mL | 0.3509 mL | 0.7018 mL | 1.7546 mL | |
| 40 mM | 0.0526 mL | 0.2632 mL | 0.5264 mL | 1.3160 mL | |
| 50 mM | 0.0421 mL | 0.2106 mL | 0.4211 mL | 1.0528 mL | |
| 60 mM | 0.0351 mL | 0.1755 mL | 0.3509 mL | 0.8773 mL | |
| 80 mM | 0.0263 mL | 0.1316 mL | 0.2632 mL | 0.6580 mL | |
| 100 mM | 0.0211 mL | 0.1053 mL | 0.2106 mL | 0.5264 mL |
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