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  3. Xantocillin

Xantocillin 

Cat. No.: HY-122404
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Xanthocillin is a marine agent extracted from Penicillium commune, induces autophagy through inhibition of the MEK/ERK pathway.

For research use only. We do not sell to patients.

Xantocillin Chemical Structure

Xantocillin Chemical Structure

CAS No. : 580-74-5

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Description

Xanthocillin is a marine agent extracted from Penicillium commune, induces autophagy through inhibition of the MEK/ERK pathway[1].

In Vitro

Xantocillin (SD118-xanthocillin X (1)) (6.9-55.56 µM; 48 hours) has a significant inhibitory effect on the proliferation of HepG2 cells with an IC50 of 22.88 ± 4.76 µM[1].
Xantocillin (SD118-xanthocillin X (1)) (24.3 µM; 12-48 hours) increases the expression of the autophagy-related genes, LC3, and Beclin 1[1].

Cell Proliferation Assay[1]

Cell Line: HepG2 cells
Concentration: 6.9 µM, 13.89 µM, 27.78 µM, 55.56 µM
Incubation Time: 48 hours
Result: A concentration-dependent inhibitory effect on cellular growth in the HepG2 cells with the IC50 of 22.88 ± 4.76 µM.

Western Blot Analysis[1]

Cell Line: HepG2 cells
Concentration: 24.3 µM
Incubation Time: 12 hours, 24 hours, 48 hours
Result: Increased the expression of the autophagy-related genes, LC3, and Beclin 1.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

288.30

Formula

C₁₈H₁₂N₂O₂

CAS No.

580-74-5

SMILES

[C-]#[N+]C(/C([N+]#[C-])=C/C1=CC=C(O)C=C1)=C\C2=CC=C(O)C=C2

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Room temperature in continental US; may vary elsewhere

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Product Name:
Xantocillin
Cat. No.:
HY-122404
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Xantocillin

Cat. No.: HY-122404