1. MAPK/ERK Pathway
    Stem Cell/Wnt
    Autophagy
  2. MEK
    ERK
    Autophagy
  3. Xantocillin

Xantocillin (Synonyms: Xanthocillin X)

Cat. No.: HY-122404
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Xantocillin (Xanthocillin X) is a marine agent extracted from Penicillium commune, induces autophagy through inhibition of the MEK/ERK pathway.

For research use only. We do not sell to patients.

Xantocillin Chemical Structure

Xantocillin Chemical Structure

CAS No. : 580-74-5

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Description

Xantocillin (Xanthocillin X) is a marine agent extracted from Penicillium commune, induces autophagy through inhibition of the MEK/ERK pathway[1].

In Vitro

Xantocillin (SD118-xanthocillin X (1)) (6.9-55.56 µM; 48 hours) has a significant inhibitory effect on the proliferation of HepG2 cells with an IC50 of 22.88 ± 4.76 µM[1].
Xantocillin (SD118-xanthocillin X (1)) (24.3 µM; 12-48 hours) increases the expression of the autophagy-related genes, LC3, and Beclin 1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: HepG2 cells
Concentration: 6.9 µM, 13.89 µM, 27.78 µM, 55.56 µM
Incubation Time: 48 hours
Result: A concentration-dependent inhibitory effect on cellular growth in the HepG2 cells with the IC50 of 22.88 ± 4.76 µM.

Western Blot Analysis[1]

Cell Line: HepG2 cells
Concentration: 24.3 µM
Incubation Time: 12 hours, 24 hours, 48 hours
Result: Increased the expression of the autophagy-related genes, LC3, and Beclin 1.
Molecular Weight

288.30

Formula

C18H12N2O2

CAS No.
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Xantocillin
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