2. MAPK/ERK Pathway Stem Cell/Wnt Autophagy
  3. MEK ERK Autophagy
  4. Xantocillin

Xantocillin (Xanthocillin X) is a marine agent extracted from Penicillium commune, induces autophagy through inhibition of the MEK/ERK pathway.

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Xantocillin Chemical Structure

Xantocillin Chemical Structure

CAS No. : 580-74-5

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Xantocillin Related Antibodies

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Description

Xantocillin (Xanthocillin X) is a marine agent extracted from Penicillium commune, induces autophagy through inhibition of the MEK/ERK pathway[1].

In Vitro

Xantocillin (SD118-xanthocillin X (1)) (6.9-55.56 µM; 48 hours) has a significant inhibitory effect on the proliferation of HepG2 cells with an IC50 of 22.88 ± 4.76 µM[1].
Xantocillin (SD118-xanthocillin X (1)) (24.3 µM; 12-48 hours) increases the expression of the autophagy-related genes, LC3, and Beclin 1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Xantocillin Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HepG2 cells
Concentration: 6.9 µM, 13.89 µM, 27.78 µM, 55.56 µM
Incubation Time: 48 hours
Result: A concentration-dependent inhibitory effect on cellular growth in the HepG2 cells with the IC50 of 22.88 ± 4.76 µM.

Western Blot Analysis[1]

Cell Line: HepG2 cells
Concentration: 24.3 µM
Incubation Time: 12 hours, 24 hours, 48 hours
Result: Increased the expression of the autophagy-related genes, LC3, and Beclin 1.
Molecular Weight

288.30

Formula

C18H12N2O2
CAS No.
SMILES

[C-]#[N+]C(/C([N+]#[C-])=C/C1=CC=C(O)C=C1)=C\C2=CC=C(O)C=C2
Structure Classification
Initial Source

Marine-Associated Fungus Penicillium sp. ZZ1750
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Xantocillin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Xantocillin580-74-5Xanthocillin XMEKERKAutophagyMitogen-activated protein kinase kinaseMAPKKMAP2KExtracellular signal regulated kinasesInhibitorinhibitorinhibit

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