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Cat. No.: HY-103663A

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MAK683 hydrochloride

4 Cited Publications

Customer Review

Based on 4 publication(s) in Google Scholar

MAK683 hydrochloride is an embryonic ectoderm development (EED) inhibitor extracted from patent US20160176882 A1, compound example 2. MAK683 exhibits IC₅₀s of 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay.

For research use only. We do not sell to patients.

CAS No.: 2170606-94-5
Formula: C₂₀H₁₈ClFN₆O
Molecular Weight:412.85

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

MAK683 hydrochloride Chemical Structure

CAS No.: 2170606-94-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Histone Methyltransferase Isoforms :

Chemical Information

CAS No. 2170606-94-5
Molecular Weight 412.85
Formula C₂₀H₁₈ClFN₆O
SMILES

CC1=NC=CC=C1C2=CN=C(NCC3=C4CCOC4=CC=C3F)N5C2=NN=C5.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (4)

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Cell Death Dis

Induction of senescence-associated secretory phenotype underlies the therapeutic efficacy of PRC2 inhibition in cancer. [Abstract]

2022 Feb 15;13(2):155. PMID: 35169119
Commun Biol

Mettl3/Eed/Ythdc1 regulatory axis controls endometrial receptivity and function. [Abstract]

2025 Feb 11;8(1):215. PMID: 39934221
J Biol Chem

PPARγ and C/EBPα enable adipocyte differentiation upon inhibition of histone methyltransferase PRC2 in malignant tumors. [Abstract]

2024 Sep 12:107765. PMID: 39276936
bioRxiv

Dual EZH1/2 inhibition enhances DNMT inhibitor efficacy in colon cancer through targeting H3K27me1. [Abstract]

2025 Sep 18:2025.09.16.676613. PMID: 41000734

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chan, Ho Man, et al. TRIAZOLOPYRIMIDINE COMPOUNDS AND USES THEREOF. US20160176882 A1.

[2]. Huang D, et al. Binding Modes of Small-Molecule Inhibitors to the EED Pocket of PRC2. Chemphyschem. 2020 Feb 4;21(3):263-271. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MAK683 hydrochloride

4 Cited Publications

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Publications (4)
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MAK683 hydrochloride

Publications Citing Use of MedChemExpress (MCE) MAK683 hydrochloride

All Histone Methyltransferase Isoforms

Biological Activity

Chemical Information

Publications (4)

Purity & Documentation

References

Calculators

Help & FAQs

MAK683 hydrochloride Related Classifications

HY-103663A Related Classifications