42-(2-Tetrazolyl)rapamycin
Based on 1 Customer Validation
42-(2-Tetrazolyl)rapamycin is a proagent compound of a rapamycin analog extracted from patent US 20080171763 A1, Example 1. Rapamycin is a specific mTOR inhibitor.
For research use only. We do not sell to patients.
- Purity: 95.78%
- CAS No.: 221877-56-1
- Formula: C52H79N5O12
- Molecular Weight:966.21
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| T-cell | IC50 |
1500 nM
Compound: 4
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Antiproliferative activity in Lewis rat lymph node cells in rat mixed lymphocyte reaction
Antiproliferative activity in Lewis rat lymph node cells in rat mixed lymphocyte reaction
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[PMID: 16185865] |
| T-cell | IC50 |
3.3 nM
Compound: 4
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T-cell antiproliferative activity in human mixed lymphocyte reaction
T-cell antiproliferative activity in human mixed lymphocyte reaction
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[PMID: 16185865] |
Chemical Information
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CAS No. 221877-56-1
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Appearance Solid
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Molecular Weight 966.21
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Formula C52H79N5O12
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Color White to off-white
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SMILES
[H][C@]1(C(O[C@@]([C@@H](C[C@H]2C[C@@H](OC)[C@@H](N3N=CN=N3)CC2)C)([H])CC([C@@H](/C=C([C@@H](O)[C@H]4OC)\C)C)=O)=O)N(C(C([C@@]5(O)[C@H](C)CC[C@](C[C@@H](/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C4=O)OC)([H])O5)=O)=O)CCCC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 130 mg/mL (134.55 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0350 mL | 5.1749 mL | 10.3497 mL | 25.8743 mL |
| 5 mM | 0.2070 mL | 1.0350 mL | 2.0699 mL | 5.1749 mL | |
| 10 mM | 0.1035 mL | 0.5175 mL | 1.0350 mL | 2.5874 mL | |
| 15 mM | 0.0690 mL | 0.3450 mL | 0.6900 mL | 1.7250 mL | |
| 20 mM | 0.0517 mL | 0.2587 mL | 0.5175 mL | 1.2937 mL | |
| 25 mM | 0.0414 mL | 0.2070 mL | 0.4140 mL | 1.0350 mL | |
| 30 mM | 0.0345 mL | 0.1725 mL | 0.3450 mL | 0.8625 mL | |
| 40 mM | 0.0259 mL | 0.1294 mL | 0.2587 mL | 0.6469 mL | |
| 50 mM | 0.0207 mL | 0.1035 mL | 0.2070 mL | 0.5175 mL | |
| 60 mM | 0.0172 mL | 0.0862 mL | 0.1725 mL | 0.4312 mL | |
| 80 mM | 0.0129 mL | 0.0647 mL | 0.1294 mL | 0.3234 mL | |
| 100 mM | 0.0103 mL | 0.0517 mL | 0.1035 mL | 0.2587 mL |
42-(2-Tetrazolyl)rapamycin Related Classifications
HY-12424A Related Classifications
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