Mutant p53 modulator-1

Cat. No.: HY-145759 Purity: 98.25%: FAQs
Data Sheet SDS COA Handling Instructions

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Mutant p53 modulator-1 is a mutant p53 modulator. Mutant p53 modulator-1 reduces the progression of cancers that contain a p53 mutation (extracted from patent WO2021231474A1, compound 231B).

For research use only. We do not sell to patients.

Mutant p53 modulator-1 Chemical Structure

CAS No. : 2746371-35-5

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 814	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 814	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 292	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 642	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1028	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 2160	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 3460	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 5540	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Mutant p53 modulator-1 is a mutant p53 modulator. Mutant p53 modulator-1 reduces the progression of cancers that contain a p53 mutation (extracted from patent WO2021231474A1, compound 231B)^[1].

Molecular Weight

576.59

Formula

C₂₇H₃₂F₄N₈O₂

CAS No.

2746371-35-5

Appearance

Solid

Color

Light yellow to brown

SMILES

FC(F)(F)CN1C2=CC=CC(N[C@H]3[C@H](CN(CC3)C)F)=C2C=C1C4=NOC(CNC(C5=CN(N=C5)C(C)(C)C)=O)=N4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (173.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7343 mL	8.6717 mL	17.3433 mL
5 mM	0.3469 mL	1.7343 mL	3.4687 mL
10 mM	0.1734 mL	0.8672 mL	1.7343 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Dosing volume
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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.25%

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (249 KB) HNMR (142 KB) RP-HPLC (302 KB) LCMS (415 KB)

Handling Instructions (2659 KB)

References

[1]. Binh Vu, et al. METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION. Patent WO2021231474A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7343 mL	8.6717 mL	17.3433 mL	43.3584 mL
	5 mM	0.3469 mL	1.7343 mL	3.4687 mL	8.6717 mL
	10 mM	0.1734 mL	0.8672 mL	1.7343 mL	4.3358 mL
	15 mM	0.1156 mL	0.5781 mL	1.1562 mL	2.8906 mL
	20 mM	0.0867 mL	0.4336 mL	0.8672 mL	2.1679 mL
	25 mM	0.0694 mL	0.3469 mL	0.6937 mL	1.7343 mL
	30 mM	0.0578 mL	0.2891 mL	0.5781 mL	1.4453 mL
	40 mM	0.0434 mL	0.2168 mL	0.4336 mL	1.0840 mL
	50 mM	0.0347 mL	0.1734 mL	0.3469 mL	0.8672 mL
	60 mM	0.0289 mL	0.1445 mL	0.2891 mL	0.7226 mL
	80 mM	0.0217 mL	0.1084 mL	0.2168 mL	0.5420 mL
	100 mM	0.0173 mL	0.0867 mL	0.1734 mL	0.4336 mL