1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR
  3. Mutated EGFR-IN-2

Mutated EGFR-IN-2 

Cat. No.: HY-128860
Handling Instructions

Mutated EGFR-IN-2 (compound 91) is a mutant-selective EGFR inhibitor extracted from patent WO2017036263A1, which potently inhibits single-mutant EGFR (T790M) and double-mutant EGFR (including L858R/T790M (IC50=<1nM) and ex19del/T790M), and can suppress activity of single gain-of-function mutant EGFR (including L858R and ex19del) as well. Mutated EGFR-IN-2 shows anti-tumor antivity.

For research use only. We do not sell to patients.

Mutated EGFR-IN-2 Chemical Structure

Mutated EGFR-IN-2 Chemical Structure

CAS No. : 2050906-97-1

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Description

Mutated EGFR-IN-2 (compound 91) is a mutant-selective EGFR inhibitor extracted from patent WO2017036263A1, which potently inhibits single-mutant EGFR (T790M) and double-mutant EGFR (including L858R/T790M (IC50=<1nM) and ex19del/T790M), and can suppress activity of single gain-of-function mutant EGFR (including L858R and ex19del) as well. Mutated EGFR-IN-2 shows anti-tumor antivity[1].

IC50 & Target[1]

EGFRT790M

 

EGFRL858R

 

EGFRex19del

 

EGFR (L858R/T790M)

<1 nM (IC50)

EGFR (ex19del/T790M)

 

Molecular Weight

562.64

Formula

C₂₉H₃₅FN₈O₃

CAS No.

2050906-97-1

SMILES

C=CC(NC1=CC(NC2=NC=CC(N3C4=CC=C(F)C=C4N(C(C)C)C3=O)=N2)=C(OC)C=C1N(CCN(C)C)C)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Mutated EGFR-IN-2
Cat. No.:
HY-128860
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