2. Anti-infection
  3. Arenavirus
  4. LHF-535

LHF-535 

Cat. No.: HY-112762 Purity: 99.20%
COA Handling Instructions

LHF-535 is an antiviral agent extracted from patent WO2013123215A2, Compound 38, has EC50s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, respectively.

For research use only. We do not sell to patients.

LHF-535 Chemical Structure

LHF-535 Chemical Structure

CAS No. : 1450929-77-7

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Solution
10 mM * 1 mL in DMSO USD 88 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 88 In-stock
Solid
5 mg USD 80 In-stock
10 mg USD 120 In-stock
50 mg USD 350 In-stock
100 mg USD 550 In-stock
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Based on 1 publication(s) in Google Scholar

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  • Purity & Documentation

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Description

LHF-535 is an antiviral agent extracted from patent WO2013123215A2, Compound 38, has EC50s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, respectively[1].

In Vitro

LHF-535 is a small-molecule viral entry inhibitor that targets the arenavirus envelope glycoprotein (GP). LHF-535 exhibits potent antiviral activity against a broad array of hemorrhagic fever arenaviruses. LHF-535 inhibits Lassa GP-pseudotyped lentivirus with an IC50 of 0.1-0.3 nM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

LHF-535 (3, 10 or 30 mg/kg; orally; daily; 14 days) protectes mice from a lethal challenge with Tacaribe virus and dramatically reduces viral titers in plasma, spleen, and liver[2].
An increase in survival is also observed when the first dose of LHF-535 (10 mg/kg) is delayed by 1, 2, or 3 days after infection, demonstrating that LHF-535 is efficacious as a post-exposure therapeutic in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: IFN-α/β and-γ receptor-deficient AG129 mice[2]
Dosage: 3, 10, or 30 mg/kg/day
Administration: Orally; daily; 14 days
Result: Effective as a post-exposure therapeutic.
Clinical Trial
Molecular Weight

412.52

Appearance

Solid

Formula

C27H28N2O2
CAS No.
SMILES

OC(C)(C)C1=CC=C(/C=C\C2=CC=C3C(N=CN3C4=CC=C(OC(C)C)C=C4)=C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 96.67 mg/mL (234.34 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4241 mL 12.1206 mL 24.2412 mL
5 mM 0.4848 mL 2.4241 mL 4.8482 mL
10 mM 0.2424 mL 1.2121 mL 2.4241 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.42 mg/mL (5.87 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.42 mg/mL (5.87 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

LHF-5351450929-77-7LHF535LHF 535ArenavirusInhibitorinhibitorinhibit

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