Arctiin
Based on 5 publication(s) in Google Scholar
Arctiin is an orally active inhibitor of NF-κB. Arctiin suppresses cyclin D1 protein expression in human tumor cells. Arctiin also reduces malondialdehyde and pro-in ammatory cytokines levels. Arctiin can used in study glomerulonephritis.
For research use only. We do not sell to patients.
- Purity: 99.52%
- CAS No.: 20362-31-6
- Formula: C27H34O11
- Molecular Weight:534.55
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Arctiin
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Customer Validation & Images
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WB
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RT-PCR
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Apoptosis Analysis
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ELISA
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Flow Cytometry
Biological Activity
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Cell Line
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Type | Value | Description | References |
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| MRC5 | CC50 |
240 μM
Compound: 8
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Cytotoxicity against MRC5 cells
Cytotoxicity against MRC5 cells
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[PMID: 17239594] |
| MRC5 | IC50 |
16 μM
Compound: 8
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Antiviral activity against HCMV in MRC5 cells by plaque reduction assay
Antiviral activity against HCMV in MRC5 cells by plaque reduction assay
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[PMID: 17239594] |
| RAW264.7 | IC50 |
>0.3 mM
Compound: 22
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs
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[PMID: 18986199] |
| RAW264.7 | IC50 |
>0.3 μM/mL
Compound: 22
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs
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[PMID: 18986199] |
Arctiin (100 μM) down-regulates cyclin D1 protein expression in human tumor cells[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HaCaT, MG63, A549, HCT116, HeLa, MCF-7, and 293T cell line
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Concentration:10, 25,100 and 250 µM
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Incubation Time:0, 6, 12, 24 and 48 h
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Result:Inhibited the HaCaT cells growth with 100 µM at 48 h.
Significantly repressed the expression of the cyclin D1 protein with 100 µM in all tumor cells.
Dephosphorylated RB protein in HaCaT cells at 48 h.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Glomerulonephritis rat model[4]
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Dosage:30, 60, and 120 mg/kg
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Administration:Oral gavage (p.o.);Once daily for 3 weeksv
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Result:Significantly decreased the levels of urine protein.
Markedly ameliorated the renal function.
Dramatically reduced IL-6 and TNF-a concentration in rat serum.
Dramatically decreased the NF-kB DNA binding activity.
Significantly reduced the MDA level and increased the SOD activity.
Chemical Information
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CAS No. 20362-31-6
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Appearance Solid
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Molecular Weight 534.55
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Formula C27H34O11
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Color White to off-white
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SMILES
O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=C(OC)C=C(C[C@H]3C(OC[C@@H]3CC4=CC(OC)=C(OC)C=C4)=O)C=C2)[C@@H]1O
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Synonyms
Arctii; NSC 315527; Arctigenin-4-glucoside
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (5)
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Journal Impact Factor
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Most Recent
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Antioxidants (Basel)
Trans-(±)-Kusunokinin Binding to AKR1B1 Inhibits Oxidative Stress and Proteins Involved in Migration in Aggressive Breast Cancer. [Abstract]2022 Nov 27;11(12):2347. PMID: 36552555 -
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Cell Immunol
Arctiin suppress Th17 cells response and ameliorates experimental autoimmune uveitis through JAK/STAT signaling. [Abstract]2025 Jan 16:409-410:104927. PMID: 39862562
Arctiin purchased from MedChemExpress. Usage Cited in: Cell Immunol. 2025 Jan 16:409-410:104927. [Abstract]
Protein immunoblot analysis was performed to examine the expression of AdipoR1 in the retina of EAU mice at day 20 treated with Arctiin (1, 10 μM).
Arctiin purchased from MedChemExpress. Usage Cited in: Cell Immunol. 2025 Jan 16:409-410:104927. [Abstract]
The mRNA expression of T cell-related inflammatory factors in the retina was determined by RT-PCR treated with Arctiin (10 μM).
Arctiin purchased from MedChemExpress. Usage Cited in: Cell Immunol. 2025 Jan 16:409-410:104927. [Abstract]
CD4+ T cells were treated with DMSO or Arctiin (0.1, 1 and 10 μM) for 48 h, then cytotoxicity of Arctiin was detected by apoptosis assay.
Arctiin purchased from MedChemExpress. Usage Cited in: Cell Immunol. 2025 Jan 16:409-410:104927. [Abstract]
The protein expression of IFN-γ, IL-17 A and IL-10 in culture supernatant was determined by ELISA treated with Arctiin (10 μM).
Arctiin purchased from MedChemExpress. Usage Cited in: Cell Immunol. 2025 Jan 16:409-410:104927. [Abstract]
CFSE labled CD4+ T cells were treated with DMSO or Arctiin (10 μM) for 96 h, then cell proliferation was detected by flow cytometry.
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Planta Med
Compound Cocktail Inhibits Influenza Viral Pneumonia via Phospholipase Cγ1 Phosphorylation-Related Necroptosis and Partial Autophagy in Natural Killer Cells. [Abstract]2021 Jun;87(7):538-549. PMID: 33545719 -
Solvent & Solubility
DMSO : 200 mg/mL (374.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 2.5 mg/mL (4.68 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (3.89 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (3.89 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 10 mg/mL (18.71 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (285 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Huang DM, et al. Modulation of anti-adhesion molecule MUC-1 is associated with arctiin-induced growth inhibition in PC-3 cells. Prostate. 2004 May 15;59(3):260-7. [Content Brief]
[2]. Knipping K, et al. In vitro and in vivo anti-allergic effects of Arctium lappa L. Exp Biol Med (Maywood). 2008 Nov;233(11):1469-77. [Content Brief]
[3]. Zeng Y, et al. Lack of significant modifying effect of arctiin on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats. Cancer Lett. 2005 May 26;222(2):145-51. [Content Brief]
[4]. Wu JG, et al. Ameliorative effects of arctiin from Arctium lappa on experimental glomerulonephritis in rats. Phytomedicine. 2009 Nov;16(11):1033-41. [Content Brief]
[5]. Ma ST, et al. Effect of arctiin on glomerular filtration barrier damage in STZ-induced diabetic nephropathy rats. Phytother Res. 2013 Oct;27(10):1474-80. [Content Brief]
[6]. Matsuzaki Y, et al. Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression. Oncol Rep. 2008 Mar;19(3):721-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.8707 mL | 9.3537 mL | 18.7073 mL | 46.7683 mL |
| DMSO | 5 mM | 0.3741 mL | 1.8707 mL | 3.7415 mL | 9.3537 mL |
| 10 mM | 0.1871 mL | 0.9354 mL | 1.8707 mL | 4.6768 mL | |
| 15 mM | 0.1247 mL | 0.6236 mL | 1.2472 mL | 3.1179 mL | |
| 20 mM | 0.0935 mL | 0.4677 mL | 0.9354 mL | 2.3384 mL | |
| 25 mM | 0.0748 mL | 0.3741 mL | 0.7483 mL | 1.8707 mL | |
| 30 mM | 0.0624 mL | 0.3118 mL | 0.6236 mL | 1.5589 mL | |
| 40 mM | 0.0468 mL | 0.2338 mL | 0.4677 mL | 1.1692 mL | |
| 50 mM | 0.0374 mL | 0.1871 mL | 0.3741 mL | 0.9354 mL | |
| 60 mM | 0.0312 mL | 0.1559 mL | 0.3118 mL | 0.7795 mL | |
| 80 mM | 0.0234 mL | 0.1169 mL | 0.2338 mL | 0.5846 mL | |
| 100 mM | 0.0187 mL | 0.0935 mL | 0.1871 mL | 0.4677 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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