(Rac)-ErSO-DFP
(Rac)-ErSO-DFP is a derivative of ErSO-DFP and a selective small molecule Erα biomodulator. (Rac)-ErSO-DFP againsts ERα+ breast cancer (including resistant tumors) by hyperactiving the Erα-dependent a-UPR (extracted from patent WO2022087234A1).
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- CAS No.: 2768139-73-5
- Formule: C20H17F5N2O2
- Masse moléculaire:412.35
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Activité biologique
Description
IC50 & Target
IC50: 35 nM (MCF-7 cells)[1].
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
0.035 μM
Compound: 2
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Anticancer activity against human MCF7 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay
Anticancer activity against human MCF7 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay
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[PMID: 35080871] |
In Vitro
(Rac)-ErSO-DFP (compound 2) (0.001-1 µM; 24 h) maintains potent anticancer activity with IC50 of 35 nM in MCF-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 cells
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Concentration:0.001-1 µM
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Incubation Time:24 h
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Result:Showed a sustained activity of anticancer with IC50 of 35 nM.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Ovariectomized Nu/J mice (MCF-7 orthotopic tumor model)[1].
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Dosage:5 mg/kg
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Administration:Intravenous injection; once-a-week for 3 total doses.
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Result:Maintained the ability to regress MCF-7 tumors in a mouse model of ERα+ breast cancer.
Chemical Information
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CAS No. 2768139-73-5
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Masse moléculaire 412.35
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Formule C20H17F5N2O2
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SMILES
O=C1NC2=C(C=CC=C2C1(N3CCC(F)(CC3)F)C4=CC=C(C=C4)O)C(F)(F)F
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(Rac)-ErSO-DFP Related Classifications
HY-144070A Related Classifications
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