(Rac)-ErSO-DFP
(Rac)-ErSO-DFP is a derivative of ErSO-DFP and a selective small molecule Erα biomodulator. (Rac)-ErSO-DFP againsts ERα+ breast cancer (including resistant tumors) by hyperactiving the Erα-dependent a-UPR (extracted from patent WO2022087234A1).
For research use only. We do not sell to patients.
- CAS No.: 2768139-73-5
- Formula: C20H17F5N2O2
- Molecular Weight:412.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 35 nM (MCF-7 cells)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
0.035 μM
Compound: 2
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Anticancer activity against human MCF7 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay
Anticancer activity against human MCF7 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay
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[PMID: 35080871] |
(Rac)-ErSO-DFP (compound 2) (0.001-1 µM; 24 h) maintains potent anticancer activity with IC50 of 35 nM in MCF-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 cells
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Concentration:0.001-1 µM
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Incubation Time:24 h
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Result:Showed a sustained activity of anticancer with IC50 of 35 nM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Ovariectomized Nu/J mice (MCF-7 orthotopic tumor model)[1].
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Dosage:5 mg/kg
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Administration:Intravenous injection; once-a-week for 3 total doses.
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Result:Maintained the ability to regress MCF-7 tumors in a mouse model of ERα+ breast cancer.
Chemical Information
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CAS No. 2768139-73-5
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Molecular Weight 412.35
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Formula C20H17F5N2O2
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SMILES
O=C1NC2=C(C=CC=C2C1(N3CCC(F)(CC3)F)C4=CC=C(C=C4)O)C(F)(F)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(Rac)-ErSO-DFP Related Classifications
HY-144070A Related Classifications
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