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  4. Cinobufotalin

Cinobufotalin 

Cat. No.: HY-N0880 Purity: 99.87%
Handling Instructions

Cinobufotalin is a cardiotonic steroids or bufadienolides, is extracted from the skin secretions of the giant toads. Cinobufotalin has been used as a cardiotonic, diuretic and a hemostatic agent, Cinobufotalin is also a potential anti-lung cancer agent.

For research use only. We do not sell to patients.

Cinobufotalin Chemical Structure

Cinobufotalin Chemical Structure

CAS No. : 1108-68-5

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 131 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 131 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 119 In-stock
Estimated Time of Arrival: December 31
10 mg USD 198 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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Description

Cinobufotalin is a cardiotonic steroids or bufadienolides, is extracted from the skin secretions of the giant toads. Cinobufotalin has been used as a cardiotonic, diuretic and a hemostatic agent, Cinobufotalin is also a potential anti-lung cancer agent[1].

In Vitro

Cinobufotalin (0.1-10 µM; 72 hours; A549, H460 and HTB-58 human lung cancer cells) treatment induces cytotoxic effect against lung cancer cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: A549, H460 and HTB-58 human lung cancer cells
Concentration: 0.1 µM, 0.5 µM, 1 µM, 5 µM, 10 µM
Incubation Time: 72 hours
Result: Significantly induced cell death in a concentration-dependent manner.
In Vivo

Cinobufotalin (1-5 mg/kg; intraperitoneal injection; twice daily; for 1 weeks; male nude mice) treatment inhibits A549 lung cancer cell growth in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male nude mice (4-6 weeks old, BALB/c) with A549 cells[1]
Dosage: 1 mg/kg or 5 mg/kg
Administration: Intraperitoneal injection; twice daily; for 1 weeks
Result: Inhibited A549 lung cancer cell growth in vivo.
Clinical Trial
Molecular Weight

458.54

Formula

C26H34O7

CAS No.
SMILES
Structure Classification
Source

toad

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (272.60 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1808 mL 10.9042 mL 21.8083 mL
5 mM 0.4362 mL 2.1808 mL 4.3617 mL
10 mM 0.2181 mL 1.0904 mL 2.1808 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (4.73 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.17 mg/mL (4.73 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (4.73 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 99.87%

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Product Name:
Cinobufotalin
Cat. No.:
HY-N0880
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