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Cinobufagin (Synonyms: Cinobufagine)

Cat. No.: HY-N0421 Purity: 98.05%
Handling Instructions

Cinobufagin, a kind of Chinese materia medica with antitumor effect, is widely used in clinical practice, especially in anti-liver cancer.

For research use only. We do not sell to patients.

Cinobufagin Chemical Structure

Cinobufagin Chemical Structure

CAS No. : 470-37-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 172 In-stock
Estimated Time of Arrival: December 31
5 mg USD 156 In-stock
Estimated Time of Arrival: December 31
10 mg USD 282 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Description

Cinobufagin, a kind of Chinese materia medica with antitumor effect, is widely used in clinical practice, especially in anti-liver cancer. IC50 value: Target: In vitro: Cinobufagin inhibited proliferation of cancer cells at doses of 0.1, 1, or 10 μM after 2–4 days of culture. Cytotoxicity of cinobufagin on the DU145 and LNCaP cells was dose-dependent. Cinobufagin increased [Ca2+]i and apoptosis in cancer cells after a 24-hr culture as well as caspase 3 activities in DU145 and PC3 cells and caspase 9 activities in LNCaP cells [1]. Cinobufagin suppresses cell proliferation and causees apoptosis in prostate cancer cells via a sequence of apoptotic modulators, including Bax, cytochrome c and caspases [2]. In vivo:

Molecular Weight

442.54

Formula

C₂₆H₃₄O₆

CAS No.

470-37-1

SMILES
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Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 43 mg/mL (97.17 mM)

*"≥" means soluble, but saturation unknown.

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2597 mL 11.2984 mL 22.5968 mL
5 mM 0.4519 mL 2.2597 mL 4.5194 mL
10 mM 0.2260 mL 1.1298 mL 2.2597 mL
*Please refer to the solubility information to select the appropriate solvent.
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Cinobufagin
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HY-N0421
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