1. Immunology/Inflammation
  2. Thrombopoietin Receptor
  3. TPO agonist 1

TPO agonist 1 

Cat. No.: HY-100380 Purity: 95.58%
Handling Instructions

TPO agonist 1 is a thrombopoietin (TPO) agonist extracted from patent WO2008134338A1, compound TPO mimetic. It would be useful as promoters of thrombopoiesis and megakaryocytopoiesis to treat thrombocytopenia.

For research use only. We do not sell to patients.

TPO agonist 1 Chemical Structure

TPO agonist 1 Chemical Structure

CAS No. : 1033040-23-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 172 In-stock
Estimated Time of Arrival: December 31
2 mg USD 120 In-stock
Estimated Time of Arrival: December 31
5 mg USD 168 In-stock
Estimated Time of Arrival: December 31
10 mg USD 264 In-stock
Estimated Time of Arrival: December 31
50 mg USD 900 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1440 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

TPO agonist 1 is a thrombopoietin (TPO) agonist extracted from patent WO2008134338A1, compound TPO mimetic. It would be useful as promoters of thrombopoiesis and megakaryocytopoiesis to treat thrombocytopenia[1].

IC50 & Target

TPO receptor[1]

In Vivo

The thrombopoietin (TPO) receptor agonists are novel treatments for patients with chronic ITP aimed at increasing platelet production through interactions with the TPO receptor on megakaryocytes, and can increases platelet counts, decrease bleeding events and reduce the need for adjunctive or rescue treatments. The TPO receptor agonists are well-tolerated, though uncertainty remains regarding the risk of thromboembolism and bone marrow fibrosis[2].

Molecular Weight

466.49

Formula

C₂₅H₂₂N₈O₂

CAS No.

1033040-23-1

SMILES

O=C(N(C1=CC=C(C)C(C)=C1)N=C/2C)C2=N\NC3=C(O)C(C4=CC=CC(C5=NN=NN5)=C4)=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 36 mg/mL (77.17 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1437 mL 10.7183 mL 21.4367 mL
5 mM 0.4287 mL 2.1437 mL 4.2873 mL
10 mM 0.2144 mL 1.0718 mL 2.1437 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2 mg/mL (4.29 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2 mg/mL (4.29 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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TPO agonist 1
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HY-100380
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