Tenacissoside H  (Synonyms: Tenacissimoside C)

Tenacissoside H is a Chinese medicine monomer extracted, isolated from Caulis Marsdeniae Tenacissimae. IC50 value: Target: In vitro: TDH significantly inhibited cells proliferation in a time-and-dose-dependent manner. TDH arrested the cell cycle in S phase and significantly inhibited PI3K and NF-κB mRNA expression, compared with blank controlled group (P < 0.05). [1] In vivo: TDH strongly inhibits tumor growth and volume. PCNA expression was significantly decreased after treatment of TDH. TDH downregulated proteins expression in PI3K/Akt-NF-κB transduction cascade (P < 0.05). [1]

794.97

Solid

C₄₂H₆₆O₁₄

191729-45-0

C[[email protected]@]([[email protected]@H]([[email protected]@H](OC(C(C)CC)=O)[[email protected]]1([H])[[email protected]]23C)OC(C)=O)([[email protected]@H]4C(C)=O)[[email protected]]5(CC4)[[email protected]@]1(CC[[email protected]@]2([H])C[[email protected]@H](O[[email protected]@](O[[email protected]](C)[[email protected]]6O[[email protected]@](O[[email protected]](C)[[email protected]@H](O)[[email protected]]7OC)([H])[[email protected]@H]7O)([H])C[[email protected]]6OC)CC3)O5

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Jia YS, et al. Antitumor Activity of Tenacissoside H on Esophageal Cancer through Arresting Cell Cycle and Regulating PI3K/Akt-NF-κB Transduction Cascade. Evid Based Complement Alternat Med. 2015;2015:464937.