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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13629
    Etoposide
    Maximum Cited Publications
    174 Publications Verification

    VP-16; VP-16-213

    		 Topoisomerase Autophagy Mitophagy Bacterial Apoptosis Antibiotic Infection Cancer
    Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .
    Etoposide
  • HY-13605
    Cytarabine
    90+ Cited Publications

    Cytosine β-D-arabinofuranoside; Cytosine Arabinoside; Ara-C

    		 DNA/RNA Synthesis Nucleoside Antimetabolite/Analog HSV Autophagy Apoptosis Endogenous Metabolite Orthopoxvirus Infection Cancer
    Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV. Cytarabine shows anti-orthopoxvirus activity.
    Cytarabine
  • HY-13605A
    Cytarabine hydrochloride
    90+ Cited Publications

    Cytosine β-D-arabinofuranoside hydrochloride; Cytosine Arabinoside hydrochloride; Ara-C hydrochloride

    		 DNA/RNA Synthesis Nucleoside Antimetabolite/Analog HSV Autophagy Infection Cancer
    Cytarabine hydrochloride, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine hydrochloride has antiviral effects against HSV.
    Cytarabine hydrochloride
  • HY-101266
    Milademetan
    5 Publications Verification

    DS-3032

    		 MDM-2/p53 E1/E2/E3 Enzyme Apoptosis Cancer
    Milademetan (DS-3032) is a specific and orally active MDM2 inhibitor for the research of acute myeloid leukemia (AML) or solid tumors. Milademetan (DS-3032) induces G1 cell cycle arrest, senescence and apoptosis .
    Milademetan
  • HY-N6722
    Swainsonine
    1 Publications Verification

    Tridolgosir

    		 Apoptosis Antibiotic Infection Cancer
    Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible α-mannosidase inhibitor. Swainsonine induces apoptosis and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity .
    Swainsonine
  • HY-13630
    Etoposide phosphate
    170+ Cited Publications

    BMY-40481

    		 Topoisomerase Bacterial Autophagy Apoptosis Infection Neurological Disease Cancer
    Etoposide phosphate (BMY-40481) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate is the phosphate ester proagent of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate induces cell cycle arrest, apoptosis, and autophagy.
    Etoposide phosphate
  • HY-N0036
    Costunolide
    5+ Cited Publications

    (+)-Costunolide; Costus lactone

    		 Apoptosis Endogenous Metabolite Cancer
    Costunolide ((+)-Costunolide) is a naturally occurring sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells .
    Costunolide
  • HY-13216
    Pyroxamide
    5+ Cited Publications

    		 HDAC Apoptosis Cancer
    Pyroxamide is a potent inhibitor of histone deacetylase 1 (HDAC1) with an ID50 of 100 nM. Pyroxamide can induce apoptosis and cell cycle arrest in leukemia .
    Pyroxamide
  • HY-13566
    Belotecan
    2 Publications Verification

    CKD-602 free base

    		 Topoisomerase Apoptosis Cancer
    Belotecan (CKD-602 free base) is a DNA topoisomerase I inhibitor. Belotecan induces cell apoptosis and cell-cycle arrest. Belotecan is a camptothecin analogue with anti-tumor effects, it can be used for the research of cancer .
    Belotecan
  • HY-100508
    ITSA-1
    15+ Cited Publications

    		 HDAC Cancer
    ITSA-1 is an activator of histone deacetylase (HDAC), and counteract trichostatin A (TSA)-induced cell cycle arrest, histone acetylation, and transcriptional activation .
    ITSA-1
  • HY-19331
    WZB117
    20+ Cited Publications

    		 GLUT Cancer
    WZB117 is a glucose transporter 1 (Glut1) inhibitor, which downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo.
    WZB117
  • HY-124955
    proTAME
    5+ Cited Publications

    		 APC Cancer
    proTAME, a cell-permeable proagent form of TAME, is an anaphase promoting complex/cyclosome (APC/C) inhibitor. proTAME causes cell cycle arrest in metaphase .
    proTAME
  • HY-110111
    T2AA
    2 Publications Verification

    		 DNA/RNA Synthesis Cancer
    T2AA is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that prevents DNA repair, increases double-strand break (DSB) formation and promotes necroptosis and cell cycle arrest in G1 phase .
    T2AA
  • HY-157122
    VJDT
    3 Publications Verification

    		 TREM receptor Transmembrane Glycoprotein Akt PI3K Interleukin Related NF-κB Inflammation/Immunology Cancer
    VJDT is a TREM1 inhibitor that can effectively block TREM1 signaling. VJDT inhibits tumor cell proliferation and migration and induces cell cycle arrest. VJDT has immunomodulatory and antitumor activities, and can be used for the research of tumors such as melanoma .
    VJDT
  • HY-N0800
    Protosappanin B
    2 Publications Verification

    (-)-Protosappanin B

    		 Apoptosis Cancer
    Protosappanin B is a phenolic compound extracted from Caesalpinia sappan. Anti-cancer activity . Protosappanin B induces apoptosis and causes G1 cell cycle arrest in human bladder cancer cells .
    Protosappanin B
  • HY-13768
    Topotecan
    35+ Cited Publications

    SKF 104864A; NSC 609669

    		 Topoisomerase Autophagy Apoptosis Cancer
    Topotecan (SKF 104864A; NSC 609669) is an orally active and potent Topoisomerase I inhibitor. Topotecan induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan shows anticancer activity .
    Topotecan
  • HY-N7000
    Perillyl alcohol

    		Environmental Pollutants Caspase Reactive Oxygen Species (ROS) Apoptosis Akt Ras Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
    Perillyl alcohol is an orally active monoterpene. Perillyl alcohol exhibits multiple activities such as analgesic, anti-inflammatory, anti-tumor, anti-angiogenic, and anti-nociceptive effects. Perillyl alcohol can induce apoptosis and cell cycle arrest in tumor cells .
    Perillyl alcohol
  • HY-18621
    OTS514
    3 Publications Verification

    		 TOPK Apoptosis Cancer
    OTS514 is a highly potent TOPK inhibitor with an IC50 of 2.6 nM. OTS514 strongly suppresses the growth of TOPK-positive cancer cells . OTS514 induces cell cycle arrest and apoptosis .
    OTS514
  • HY-N0211
    Cyasterone
    2 Publications Verification

    		 EGFR Apoptosis Cancer
    Cyasterone, a natural EGFR inhibitor, mainly isolated from Ajuga decumbens Thunb (Labiatae). Cyasterone manifests anti-proliferation effect by induced apoptosis and cell cycle arrests. Cyasterone may serves as a therapeutic anti-tumor agent against human tumors .
    Cyasterone
  • HY-15611
    KPT-185

    		CRM1 Cancer
    KPT-185 is an orally bioavailable and selective inhibitor of CRM1 and displays potent antiproliferative properties at submicromolar concentrations (IC50=100-500 nM), induces apoptosis, cell-cycle arrest, and myeloid differentiation in AML cell lines and patient blasts .
    KPT-185
  • HY-N6038
    Gartanin

    		Autophagy Fungal Cancer
    Gartanin is a natural xanthone of mangosteen, with antioxidant, anti-inflammatory, antifungal, neuroprotective and antineoplastic properties. Gartanin induces cell cycle arrest and autophagy and suppresses migration in human glioma cells .
    Gartanin
  • HY-116446
    Pironetin

    		Microtubule/Tubulin Cancer
    Pironetin is an α/β unsaturated lactone isolated from Streptomyces species. Pironetin binds to α-tubulin and is a potent inhibitor of microtubule polymerization, and has cell cycle arrest and antitumor activity .
    Pironetin
  • HY-N1925
    Tea polyphenol
    2 Publications Verification

    		 Apoptosis Autophagy Neurological Disease Inflammation/Immunology Cancer
    Tea polyphenol is the floorboard of phenolic compounds in tea. Tea polyphenol exhibits biological activity including antioxidant and anti-cancer activities, inhibition of cell proliferation, induction of apoptosis, cell cycle arrest and modulation of carcinogen metabolism .
    Tea polyphenol
  • HY-120836
    AOH1160
    1 Publications Verification

    		 DNA/RNA Synthesis Apoptosis Cancer
    AOH1160 is a potent oral small molecule proliferating cell nuclear antigen (PCNA) inhibitor that interferes with DNA replication, blocks homologous recombination-mediated DNA repair, leads to cell cycle arrest and induces apoptosis .
    AOH1160
  • HY-N6843
    Arnicolide D
    2 Publications Verification

    		 Caspase PI3K Akt mTOR STAT Apoptosis NF-κB Reactive Oxygen Species (ROS) Cancer
    Arnicolide D is a sesquiterpene lactone that can be isolated from Centipeda minima. Arnicolide D is cytotoxic to tumor cells and can induce cell cycle arrest, apoptosis, and oncosis in tumor cells. Arnicolide D has anti-tumor activity .
    Arnicolide D
  • HY-120140
    Ganoderic acid DM
    1 Publications Verification

    		 Apoptosis PI3K Metabolic Disease Inflammation/Immunology Cancer
    Ganoderic acid DM, a natural triterpenoid isolated from Ganoderma lucidum, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Ganoderic acid DM as a specific inhibitor of osteoclastogenesis .
    Ganoderic acid DM
  • HY-124632
    WJ460
    3 Publications Verification

    		 Ferroptosis Autophagy Cancer
    WJ460 is a potent inhibitor of myoferlin (MYOF) that interacts directly with MYOF. WJ460 inhibits the migration and growth, induces cell cycle arrest, mitochondrial autophagy, lipid peroxidation and ferroptosis in tumor cells. WJ460 has anti-tumor activity .
    WJ460
  • HY-111428
    Phleomycin D1
    2 Publications Verification

    PLM D1

    		 Antibiotic Infection
    Phleomycin D1 (PLM D1), a glycopeptide antibiotic, is a member of the Bleomycin/Phleomycin family. Phleomycin D1 causes cell death by binding and cleaving DNA. Phleomycin D1 induces cell cycle arrest at S phase .
    Phleomycin D1
  • HY-N6623
    Malvidin-3-galactoside chloride
    1 Publications Verification

    		 Apoptosis Endogenous Metabolite Reactive Oxygen Species (ROS) Cancer
    Malvidin-3-galactoside chloride, an anthocyanin monomer, induces hepatocellular carcinoma (HCC) cells cycle arrest and apoptosis. Malvidin-3-galactoside chloride inhibits the production and accumulation of ROS. Malvidin-3-galactoside chloride has anti-tumor function .
    Malvidin-3-galactoside chloride
  • HY-13563
    Batabulin

    T138067

    		 Microtubule/Tubulin Apoptosis Cancer
    Batabulin (T138067) is an antitumor agent, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to cell-cycle arrest ultimately induces apoptotic cell death .
    Batabulin
  • HY-118034
    MTBT
    1 Publications Verification

    		 p38 MAPK Apoptosis Cancer
    MTBT is an anticancer agent and p38 MAPK activator. MTBT can inhibit tumor cell proliferation, induce cell cycle arrest and apoptosis. MTBT increases the phosphorylation of histone H3 serine in cancer cells, thereby arresting the cell cycle in the M phase. The specific inhibitor of p38 MAPK, Adezmapimod (HY-10256), can abrogate the cell cycle arrest induced by MTBT .
    MTBT
  • HY-111299
    Psammaplysene A

    		Apoptosis Cancer
    Psammaplysene A, a brominated tyrosine derivative, can promote the nuclear localization of FOXO1, leading to cell cycle arrest and apoptosis, and can be used in cancer research .
    Psammaplysene A
  • HY-N7707
    Sandacanol

    		Environmental Pollutants Apoptosis Cancer
    Sandacanol is a specific agonist of olfactory receptor (OR10H1). Sandacanol induces cell cycle arrest and some apoptosis in bladder cancer cells .
    Sandacanol
  • HY-N1516
    Ganoderenic acid D

    		Apoptosis Cancer
    Ganoderenic acid D is a triterpene identified from the effective compounds of Ganoderma lucidum extract (GLE). Ganoderenic acid D inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis .
    Ganoderenic acid D
  • HY-N11774
    Euphornin

    		Apoptosis Caspase Cancer
    Euphornin is a anticaner agent, that can be isolated from E. helioscopia. Euphornin induces apoptosis via caspase-mediated pathways. Euphornin induces cell cycle arrest by increasing the level of the phospho-CDK1 (Tyr15) protein .
    Euphornin
  • HY-13563A
    Batabulin sodium

    T138067 sodium

    		 Microtubule/Tubulin Apoptosis Cancer
    Batabulin sodium (T138067 sodium) is an antitumor agent, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin sodium affects cell morphology and leads to cell-cycle arrest ultimately induces apoptotic cell death .
    Batabulin sodium
  • HY-155339
    Anticancer agent 168

    		Apoptosis DNA/RNA Synthesis Cancer
    Anticancer agent 168 (compound d16) is a inhibitor of DNA2. Anticancer agent 168 induces apoptosis and cell-cycle arrest mainly at S-phase, and exhibits anticancer activities and overcomes chemotherapy resistance in mutp53-bearing cancers .
    Anticancer agent 168
  • HY-113471
    Perillic acid

    		Apoptosis HSV Infection Inflammation/Immunology Cancer
    Perillic acid is the metabolite of Perillyl alcohol (HY-N7000). Perillic acid induces lung cancer cell cycle arrest and apoptosis. Perillic acid shows anti-HSV-1 and immunomodulatory activities .
    Perillic acid
  • HY-136489
    KU-0058948

    		PARP Apoptosis Cancer
    KU-0058948 is a specific and potent PARP1 inhibitor with an IC50 of 3.4 nM. KU-0058948 induces cell cycle arrest and apoptosis of primary myeloid leukemic cells and myeloid leukemic cell lines .
    KU-0058948
  • HY-101266B
    Milademetan tosylate hydrate
    5 Publications Verification

    DS-3032b; DS-3032 tosylate hydrate

    		 MDM-2/p53 E1/E2/E3 Enzyme Apoptosis Cancer
    Milademetan (DS-3032) tosylate hydrate is a specific and orally active MDM2 inhibitor for the research of acute myeloid leukemia (AML) or solid tumors. Milademetan (DS-3032) tosylate hydrate induces G1 cell cycle arrest, senescence and apoptosis .
    Milademetan tosylate hydrate
  • HY-W718423
    Isodecyl diphenyl phosphate

    IDPP

    		 DNA/RNA Synthesis MDM-2/p53 Cancer
    Isodecyl diphenyl phosphate (IDPP) is a flame retardant. Isodecyl diphenyl phosphate induces cytotoxicity, DNA damage, mitochondrial dysfunction and oxidative stress in cancer cells, and mediates DNA damage and cell cycle arrest via a p53-dependent pathway .
    Isodecyl diphenyl phosphate
  • HY-N7496
    Odoroside A

    		Apoptosis Cancer
    Odoroside A is an active ingredient extracted from the leaves of Nerium oleander Linn. Odoroside A has anti-cancer activity. Odoroside A could induce apoptosis and cell cycle arrest through ROS/p53 signaling pathway, leading to the tumor cell death .
    Odoroside A
  • HY-178908
    FLT3-IN-35

    		FLT3 Apoptosis Cancer
    FLT3-IN-35 (Compound 4K) is an orally active, covalent, irreversible FLT3 inhibitor. FLT3-IN-35 inhibits the phosphorylation of FLT3 and its downstream signaling factors, as well as induces cell cycle arrest and apoptosis. FLT3-IN-35 inhibits the phosphorylation of FLT3 and its downstream signaling factors, as well as induced cell cycle arrest and apoptosis. FLT3-IN-35 can be used for the study of acute myeloid leukemia (AML) .
    FLT3-IN-35
  • HY-N4171
    Dihydrocucurbitacin B

    		Apoptosis Inflammation/Immunology
    Dihydrocucurbitacin B, a triterpene isolated from Cayaponia tayuya roots, inhibits nuclear factor of activated T cells (NFAT), induces cell cycle arrested in the G0 phase, and inhibits delayed type hypersensitivity .
    Dihydrocucurbitacin B
  • HY-126423
    Isorhamnetin 3-glucuronide

    Isorhamnetin 3-O-glucuronide

    		 Apoptosis Cancer
    Isorhamnetin 3-glucuronide is a potent anticancer agent. Isorhamnetin 3-glucuronide shows anti-proliferative activity. Isorhamnetin 3-glucuronide induces Apoptosis and cell cycle arrest at S-phase .
    Isorhamnetin 3-glucuronide
  • HY-168620
    CDK6-IN-1

    		CDK Cancer
    CDK6-IN-1 (compound 4i) is a CDK6 inhibitor. CDK6-IN-1 inhibits cell growth and induces cell cycle arrest at G1-phase .
    CDK6-IN-1
  • HY-18952A
    (Z)-SU5614

    		FLT3 Apoptosis Cancer
    (Z)-SU5614 is a potent FLT3 inhibitor and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3 .
    (Z)-SU5614
  • HY-126412
    Neochamaejasmine A

    		Apoptosis Cancer
    Neochamaejasmine A is a biflavonoid that can be isolated from the roots of Stellera chamaejasme L.. Neochamaejasmine A inhibits proliferation, induces cell cycle arrest and apoptosis in tumor cells. Neochamaejasmine A can be used in the research of cancers such as prostate cancer, hepatoma cancer .
    Neochamaejasmine A
  • HY-N11645
    Ganoderic acid Mf

    GA-Mf

    		 Apoptosis Cancer
    Ganoderic acid Mf is an antitumor triterpenoid. Ganoderic acid Mf causes cell cycle arrest in the G1 phase. Ganoderic acid Mf shows high selectivity between normal and cancer cells and induces cell apoptosis via mitochondria mediated pathway .
    Ganoderic acid Mf
  • HY-108164
    Aspidin BB

    		Apoptosis Bcl-2 Family Caspase Cancer
    Aspidin BB is a phloroglucinol derivative, which can be isolated from the aerial part of Dryopteris championii. Aspidin BB has anticancer activity. Aspidin BB induces cell cycle arrest and apoptosis in human ovarian HO-8910 cells .
    Aspidin BB

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