1. Cell Cycle/DNA Damage Epigenetics
  2. HDAC CDK
  3. CDK/HDAC-IN-4

CDK/HDAC-IN-4 is a high selective dual cyclin-dependent kinase (CDK)/histone deacetylase (HDAC) inhibitor with IC50 values of 88.4 and 168.9 nM, respectively. CDK/HDAC-IN-4 exhibits antiproliferative capacities against hematological and solid tumor cells. CDK/HDAC-IN-4 also induces MV-4-11 cell Apoptosis and S cell cycle arrests. CDK/HDAC-IN-4 possesses a significant antitumor potency in the MV-4-11 xenograft model.

For research use only. We do not sell to patients.

CDK/HDAC-IN-4 Chemical Structure

CDK/HDAC-IN-4 Chemical Structure

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Description

CDK/HDAC-IN-4 is a high selective dual cyclin-dependent kinase (CDK)/histone deacetylase (HDAC) inhibitor with IC50 values of 88.4 and 168.9 nM, respectively. CDK/HDAC-IN-4 exhibits antiproliferative capacities against hematological and solid tumor cells. CDK/HDAC-IN-4 also induces MV-4-11 cell Apoptosis and S cell cycle arrests. CDK/HDAC-IN-4 possesses a significant antitumor potency in the MV-4-11 xenograft model[1].

Molecular Weight

634.13

Formula

C34H32ClN9O2

SMILES

ClC1=CN=C(C=C1C2=CC=CC(NCC3(CCOCC3)C#N)=N2)NC4=CN(N=C4)CC5=CC=C(C=C5)C(NC6=C(C=CC=C6)N)=O

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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CDK/HDAC-IN-4
Cat. No.:
HY-169075
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