1. Apoptosis
  2. MDM-2/p53
    Apoptosis
  3. Ziyuglycoside I

Ziyuglycoside I 

Cat. No.: HY-N0331
Handling Instructions

Ziyuglycoside I isolated from S. officinalis root, has anti-wrinkle activity, and increases the expression of type I collagen. Ziyuglycoside I could be used as an active ingredient for cosmetics. Ziyuglycoside I triggers cell cycle arrest and apoptosis mediated by p53, it can be a potential drug candidate for treating triple-negative breast cancer (TNBC).

For research use only. We do not sell to patients.

Ziyuglycoside I Chemical Structure

Ziyuglycoside I Chemical Structure

CAS No. : 35286-58-9

Size Stock
1 mg   Get quote  
5 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ziyuglycoside I isolated from S. officinalis root, has anti-wrinkle activity, and increases the expression of type I collagen. Ziyuglycoside I could be used as an active ingredient for cosmetics[1]. Ziyuglycoside I triggers cell cycle arrest and apoptosis mediated by p53, it can be a potential drug candidate for treating triple-negative breast cancer (TNBC)[2].

In Vitro

Ziyuglycoside I (5-160 µM; 24 hours) reveals a marked anti-proliferation activity with an IC50 value of 13.96 µM in MDA-MB-231 cells[2].
Ziyuglycoside I (5-20 µM; 24 hours) induces MDA-MB-231 cell apoptosis by increasing the percentage of apoptotic cells from 2.43% to 44.76% at 20 µM[2].
Ziyuglycoside I (5-20 µM; 24 hours) induces the cleavage of caspas-8, caspase-9, and caspase-3, up-regulates the pro-apoptotic protein Bax, and down-regulates anti-apoptotic protein Bal-2, dose-dependently reduces the level of mito-cyto c expression[2].

Cell Viability Assay[1]

Cell Line: MDA-MB-231 cells
Concentration: 5 µM, 10 µM, 20 µM, 40 µM, 80 µM, and 160 µM
Incubation Time: 24 hours
Result: Showed cytotoxicity on MDA-MB-231 cells.

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 5 µM, 10 µM, and 20 µM
Incubation Time: 24 hours
Result: Induced G2/M phase arrest and apoptosis on MDA-MB-231 Cells

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 5 µM, 10 µM, and 20 µM
Incubation Time: 24 hours
Result: Induced apoptosis in MDA-MB-231 Cells through Intrinsic and Extrinsic Pathways.
Molecular Weight

766.96

Formula

C₄₁H₆₆O₁₃

CAS No.

35286-58-9

SMILES
Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Ziyuglycoside I
Cat. No.:
HY-N0331
Quantity: