1. Cell Cycle/DNA Damage
    Apoptosis
    Autophagy
  2. Topoisomerase
    Apoptosis
    Autophagy
  3. Topotecan hydrochloride hydrate

Topotecan hydrochloride hydrate (Synonyms: SKF 104864A hydrochloride hydrate; NSC 609669 hydrochloride hydrate)

Cat. No.: HY-13768C
Handling Instructions

Topotecan hydrochloride hydrate is an orally active and potent Topoisomerase I inhibitor. Topotecan hydrochloride hydrate induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan hydrochloride hydrate shows anticancer activity.

For research use only. We do not sell to patients.

Topotecan hydrochloride hydrate Chemical Structure

Topotecan hydrochloride hydrate Chemical Structure

CAS No. : 1044663-62-8

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other In-stock Forms of Topotecan hydrochloride hydrate:

Other Forms of Topotecan hydrochloride hydrate:

Top Publications Citing Use of Products

    Topotecan hydrochloride hydrate purchased from MCE. Usage Cited in: Nat Commun. 2019 Aug 21;10(1):3761.

    WDR5 inhibitor OICR-9429 enhances the sensitivity of ovarian cancer to genotoxic chemotherapeutics in vivo. Representative images and the apoptotic rate the indicated chemotherapy-treated xenograft tumors.

    Topotecan hydrochloride hydrate purchased from MCE. Usage Cited in: Nat Commun. 2019 Aug 21;10(1):3761.

    IB analysis of the level of cleaved-caspase 3 and cleaved-PARP1 in the indicated chemotherapy-treated xenograft tumors. GAPDH served as the loading control.

    View All Topoisomerase Isoform Specific Products:

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Topotecan hydrochloride hydrate is an orally active and potent Topoisomerase I inhibitor. Topotecan hydrochloride hydrate induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan hydrochloride hydrate shows anticancer activity[1].

    IC50 & Target

    Topoisomerase I

     

    In Vitro

    Topotecan hydrochloride hydrate obviously inhibits proliferation of human glioma cells and glioma stem cells (GSCs) in a dose- and time-dependent manner[1].
    Topotecan hydrochloride hydrate (0-40 μM) obviously inhibits the cell viability compared with the control groups, in a dose-dependent manner[1].
    Topotecan hydrochloride hydrate shows anti-proliferation activity against U251, U87, GSCs-U251 and GSCs-U87 cells, with IC50 values of 2.73±0.25, 2.95±0.23, 5.46±0.41, and 5.95±0.24 μM, respectively[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Topotecan hydrochloride hydrate (0.5, 1.0, and 1.5 mg/kg; Orally, daily) causes greater reduction in microvascular density in an ovarian cancer model, but the mice treated with 1.5 mg/kg daily, oral Topotecan show decreased food intake, and a lesser antitumor effect[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    475.92

    Formula

    C23H26ClN3O6

    CAS No.
    SMILES

    O=C1[[email protected]](O)(CC)C2=C(CO1)C(N3CC4=CC5=C(CN(C)C)C(O)=CC=C5N=C4C3=C2)=O.Cl.O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    Purity & Documentation
    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

     

    Salutation

    Applicant Name *

     

    Email address *

    Phone number *

     

    Organization name *

    Department *

     

    Requested quantity *

    Country or Region *

         

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Topotecan hydrochloride hydrate
    Cat. No.:
    HY-13768C
    Quantity:
    MCE Japan Authorized Agent: