2. Protein Tyrosine Kinase/RTK Apoptosis
  3. Src Apoptosis
  4. Lck-IN-3

Lck-IN-3 (compound 7m) is an LCK inhibitor targeting acute lymphoblastic leukemia (ALL) that inhibits LCK phosphorylation. Lck-IN-3 can induce cell cycle arrest in the G2/M phase, leading to apoptosis in ALL cells.

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Lck-IN-3 Chemical Structure

Lck-IN-3 Chemical Structure

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Lck-IN-3 Related Antibodies

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Description

Lck-IN-3 (compound 7m) is an LCK inhibitor targeting acute lymphoblastic leukemia (ALL) that inhibits LCK phosphorylation. Lck-IN-3 can induce cell cycle arrest in the G2/M phase, leading to apoptosis in ALL cells[1].

IC50 & Target

LCK[1]
Molecular Weight

506.58

Formula

C28H22N6O2S
SMILES

O=C(C1=CC(SC(NC(CC2=CC=C(C)C=C2)=O)=N3)=C3C=C1)N4C=CC5=C4C=C(C6=CN(C)N=C6)C=N5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Lck-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lck-IN-3SrcApoptosisacute lymphoblastic leukemiacell cycle arrestInhibitorinhibitorinhibit

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