EGFR WT/T790M-IN-4
EGFR WT/T790M-IN-4 is an anticancer agent. EGFR WT/T790M-IN-4 acts as an inhibitor of EGFRWT and EGFRT790M , with an IC50 of 0.133 μM and 0.043 μM, respectively. EGFR WT/T790M-IN-4 also inhibits PI3K and mTOR kinases, with IC50 values of 0.22 μM and 0.35 μM, respectively. EGFR WT/T790M-IN-4 induces cell cycle arrest and apoptosis in cancer cells, and inhibits cancer cell proliferation. EGFR WT/T790M-IN-4 can be used in research related to prostate cancer, colon cancer and breast cancer.
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- Fòrmula: C30H27ClN4O4
- Peso molecular:543.01
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Actividad biológica
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EGFRT790M |
EGFR (WT) |
EGFR WT/T790M-IN-4 (Compound 5d) (48 h) exhibits cytotoxic activity against PC-3, Caco-2 and MDA-231 cancer cell lines, with corresponding IC50 values of 9.46 μM, 7.45 μM and 5.92 μM[1].
EGFR WT/T790M-IN-4 (5.92 μM; 24 h) induces G1/S cell cycle arrest and apoptosis in MDA-231 breast cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-231
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Concentration:5.92 μM
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Incubation Time:24 h
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Result:Induced cell cycle arrest at the G1/S phase, with G0/G1 phase cells increasing to 59.15%, S phase to 39.52%, and G2/M phase decreasing to 1.33%.
Chemical Information
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Peso molecular 543.01
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Fòrmula C30H27ClN4O4
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SMILES
O=C1N(CC(N/N=C(C)/C2=CC=CC=C2O)=O)N=C(/C=C/C3=CC=C(OC)C=C3)C=C1CC4=CC=C(Cl)C=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR WT/T790M-IN-4 Related Classifications
HY-181099 Related Classifications
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